Natural products can be used in therapeutic management of COVID-19: Probable mechanistic insights

S Ali, M Alam, F Khatoon, U Fatima, AM Elasbali… - Biomedicine & …, 2022 - Elsevier
The unexpected emergence of the new Coronavirus disease (COVID-19) has affected more
than three hundred million individuals and resulted in more than five million deaths …

Research progress on antimicrobial materials for food packaging

S Ahmed, DE Sameen, R Lu, R Li, J Dai… - Critical Reviews in …, 2022 - Taylor & Francis
Microbial contamination is an utmost cause of food spoilage. Antimicrobial agents are used
to treat microbial diseases in food. They also serve food packaging industry, as they are …

Target identification among known drugs by deep learning from heterogeneous networks

X Zeng, S Zhu, W Lu, Z Liu, J Huang, Y Zhou… - Chemical …, 2020 - pubs.rsc.org
Without foreknowledge of the complete drug target information, development of promising
and affordable approaches for effective treatment of human diseases is challenging. Here …

Rosmarinic acid exhibits anticancer effects via MARK4 inhibition

S Anwar, A Shamsi, M Shahbaaz, A Queen, P Khan… - Scientific Reports, 2020 - nature.com
Microtubule affinity regulating kinase (MARK4) is a potential drug target for different types of
cancer as it controls the early step of cell division. In this study, we have screened a series of …

Virtual screening approach to identify high-affinity inhibitors of serum and glucocorticoid-regulated kinase 1 among bioactive natural products: Combined molecular …

T Mohammad, S Siddiqui, A Shamsi, MF Alajmi… - Molecules, 2020 - mdpi.com
Serum and glucocorticoid-regulated kinase 1 (SGK1) is a serine/threonine kinase that works
under acute transcriptional control by several stimuli, including serum and glucocorticoids. It …

MARK4 inhibited by AChE inhibitors, donepezil and Rivastigmine tartrate: insights into Alzheimer's disease therapy

A Shamsi, S Anwar, T Mohammad, MF Alajmi… - Biomolecules, 2020 - mdpi.com
Microtubule affinity-regulating kinase (MARK4) plays a key role in Alzheimer's disease (AD)
development as its overexpression is directly linked to increased tau phosphorylation …

Ellagic acid controls cell proliferation and induces apoptosis in breast cancer cells via inhibition of cyclin-dependent kinase 6

M Yousuf, A Shamsi, P Khan, M Shahbaaz… - International journal of …, 2020 - mdpi.com
Cyclin-Dependent Kinase 6 (CDK6) plays an important role in cancer progression, and thus,
it is considered as an attractive drug target in anticancer therapeutics. This study presents an …

[HTML][HTML] Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications

U Fatima, S Roy, S Ahmad, LA Al-Keridis… - Biomedicine & …, 2022 - Elsevier
Bacopa monnieri (Brahmi) is a well-known perennial, creeping herb of the Indian Ayurveda
system; it contains numerous bioactive phytoconstituents implicated in the therapeutic …

Discovery of Hordenine as a potential inhibitor of pyruvate dehydrogenase kinase 3: implication in lung Cancer therapy

S Anwar, T Mohammad, A Shamsi, A Queen… - Biomedicines, 2020 - mdpi.com
Design and development of potential pyruvate dehydrogenase kinase 3 (PDK3) inhibitors
have gained attention because of their possible therapeutic uses in lung cancer therapy. In …

Identification and evaluation of bioactive natural products as potential inhibitors of human microtubule affinity-regulating kinase 4 (MARK4)

T Mohammad, FI Khan, KA Lobb, A Islam… - Journal of …, 2019 - Taylor & Francis
Microtubule affinity-regulating kinase 4 (MARK4) has recently been identified as a potential
drug target for several complex diseases including cancer, diabetes and neurodegenerative …