Solvent paramagnetic relaxation enhancement (sPRE) is a versatile nuclear magnetic
resonance (NMR)-based method that allows characterization of the structure and dynamics …

Biomolecular electrostatics has been a subject of computational investigations based on 3D
structures. This situation is changing because emerging experimental tools allow us to …

NMR spectroscopy is an important tool for the measurement of the electrostatic properties of
biomolecules. To this point, paramagnetic relaxation enhancements (PREs) of 1H nuclei …

In paramagnetic metalloproteins, longitudinal relaxation rates of 13C′ and 13Cα nuclei can
be measured using 13C detected experiments and converted into electron spin-nuclear spin …

There is ample computational, but only sparse experimental data suggesting that pico‐ns
motions with 1 Å amplitude are pervasive in proteins in solution. Such motions, if present in …

Over 40% of eukaryotic proteomes and 15% of bacterial proteomes are predicted to be
intrinsically disordered based on their amino acid sequence. Intrinsically disordered proteins …

Electrostatic interactions can play important roles in regulating various biological processes.
Quantifying surface electrostatics of biomolecules is, therefore, of significant interest. Recent …

Longitudinal (Γ1) and transverse (Γ2) solvent paramagnetic relaxation enhancement (sPRE)
yields field-dependent information in the form of spectral densities that provides unique …

Solution NMR spectroscopy is a particularly powerful technique for characterizing the
functional dynamics of biomolecules, which is typically achieved through the quantitative …

This book chapter covers relevant articles published in peer-reviewed journals in 2022 in
the field of NMR spectroscopy of small molecules in solution. Articles that appeared in 2022 …