Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …

Envenomations by Bothrops asper are often associated with complex and severe local
pathological manifestations, including edema, blistering, dermonecrosis, myonecrosis and …

Snakebite envenoming is an important public health issue responsible for mortality and
severe morbidity. Where mortality is mainly caused by venom toxins that induce …

The isolation and study of individual snake venom components paves the way for a deeper
understanding of the pathophysiology of envenomings–thus potentially contributing to …

The present work evaluates both in vitro and in vivo antitumor activity of BPB-modified BthTX-
I and its cationic synthetic peptide derived from the 115–129 C-terminal region. BPB-BthTX-I …

Snakebite envenomation is a WHO classified priority neglected disease, which manifests
multiple local and systemic toxic effects. Intravenous antivenom therapy is the treatment of …

Ikarugamycin (IKA) is an antibiotic with strong antiprotozoal and cytotoxic activity. The
purpose of our work was to provide insight into the mechanism of action characterizing the …

Acute muscle tissue damage, myonecrosis, is a typical consequence of envenomations by
snakes of the family Viperidae. Catalytically-inactive Lys49 phospholipase A2 homologues …

Currently, biological and organic substances are screened in order to find a new generation
of therapeutics active against cancer. Previous research has identified promising candidate …

Bites from snake (Bothrops genus) cause local tissue damage and systemic complications,
which include alterations such as hemostatic system and acute renal failure (ARF). Recent …