TAK-861, a potent, orally available orexin receptor 2-selective agonist, produces wakefulness in monkeys and improves narcolepsy-like phenotypes in mouse models
K Mitsukawa, M Terada, R Yamada, T Monjo… - Scientific Reports, 2024 - nature.com
Abstract Narcolepsy type 1 (NT1) is associated with severe loss of orexin neurons and
characterized by symptoms including excessive daytime sleepiness and cataplexy. Current …
characterized by symptoms including excessive daytime sleepiness and cataplexy. Current …
Effects of an OX2R agonist on migration and removal of tau from mouse brain
M Terada, K Mitsukawa, M Nakakariya, T Koike… - Scientific Reports, 2024 - nature.com
Pathological proteins including tau are produced in neurons and released into interstitial
fluid (ISF) in a neural activity-dependent manner during wakefulness. Pathological proteins …
fluid (ISF) in a neural activity-dependent manner during wakefulness. Pathological proteins …