Bioactivation of polycyclic aromatic hydrocarbon carcinogens within the vascular wall: implications for human atherogenesis
KS Ramos, B Moorthy - Drug Metabolism Reviews, 2005 - Taylor & Francis
Atherogenesis is a complex pathogenetic process involving a variety of structural and
functional deficits within the arterial wall that culminate in the formation of fibrous …
functional deficits within the arterial wall that culminate in the formation of fibrous …
Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells
AS Bélanger, J Tojcic, M Harvey, C Guillemette - BMC molecular biology, 2010 - Springer
Abstract Background UDP-glucuronosyltransferase 1A1 (UGT1A1) is a pivotal enzyme
involved in metabolism of SN-38, the active metabolite of irinotecan commonly used to treat …
involved in metabolism of SN-38, the active metabolite of irinotecan commonly used to treat …
Pathway-targeted pharmacogenomics of CYP1A2 in human liver
K Klein, S Winter, M Turpeinen, M Schwab… - Frontiers in …, 2010 - frontiersin.org
The human drug metabolizing cytochrome P450 (CYP) 1A2, is one of the major P450
isoforms contributing by about 5–20% to the hepatic P450 pool and catalyzing oxidative …
isoforms contributing by about 5–20% to the hepatic P450 pool and catalyzing oxidative …
Transcriptional activation of CYP2C9, CYP1A1, and CYP1A2 by hepatocyte nuclear factor 4α requires coactivators peroxisomal proliferator activated receptor-γ …
CP Martínez-Jiménez, JV Castell… - Molecular …, 2006 - ASPET
Hepatocyte nuclear factor 4α (HNF4α) is a key transcription factor for the constitutive
expression of cytochromes P450 (P450s) in the liver. However, human hepatoma HepG2 …
expression of cytochromes P450 (P450s) in the liver. However, human hepatoma HepG2 …
[PDF][PDF] Role of β‐catenin in the adult liver
FJ Gonzalez - Hepatology, 2006 - Wiley Online Library
With its involvement in the Wnt signal trans-duction pathway and in tumorigenesis, ß-catenin
is an intensely studied protein. 1 In tissues and quiescent cells, ß-catenin is found localized …
is an intensely studied protein. 1 In tissues and quiescent cells, ß-catenin is found localized …
Preferential inducibility of CYP1A1 and CYP1A2 by TCDD: differential regulation in primary human hepatocytes versus transformed human cells
ZY Zhang, RD Pelletier, YN Wong, M Sugawara… - Biochemical and …, 2006 - Elsevier
Cytochrome P4501A1 (CYP1A1) induction, a marker of aryl hydrocarbon (Ah) receptor
activation, has been associated with carcinogenicity of the environmental agent 2, 3, 7, 8 …
activation, has been associated with carcinogenicity of the environmental agent 2, 3, 7, 8 …
Aromatic hydrocarbon receptor regulates chicken cytochrome P450 1A5 transcription: A novel insight into T-2 toxin-induced gene expression and cytotoxicity in LMH …
Q Liu, J Wen, J Zhu, T Zhang, Y Deng, J Jiang - Biochemical pharmacology, 2019 - Elsevier
T-2 toxin is a secondary metabolite produced by the Fusarium genus and is highly toxic to
both farmed animals and humans. In our previous study, we found that chicken cytochrome …
both farmed animals and humans. In our previous study, we found that chicken cytochrome …
Pharmacogenetics of CYP1A2 activity and inducibility in smokers and exsmokers
M Dobrinas, J Cornuz, CB Eap - Pharmacogenetics and genomics, 2013 - journals.lww.com
Background There is a high interindividual variability in cytochrome P4501A2 (CYP1A2)
activity and in its inducibility by smoking, only poorly explained by known CYP1A2 …
activity and in its inducibility by smoking, only poorly explained by known CYP1A2 …
Inducibility of AhR-regulated CYP genes by β-naphthoflavone in the liver, lung, kidney and heart of the pig
V Chirulli, L Marvasi, A Zaghini, R Fiorio, V Longo… - Toxicology, 2007 - Elsevier
The presence and inducibility of CYP enzymes belonging to the family 1 (CYP 1A1, 1A2 and
1B1) and AhR have been studied in liver, lung, kidney and heart of control and beta …
1B1) and AhR have been studied in liver, lung, kidney and heart of control and beta …
Functional analysis of GC Box and its CpG methylation in the regulation of CYP1A2 gene expression
A Miyajima, T Furihata, K Chiba - Drug metabolism and pharmacokinetics, 2009 - Elsevier
Although there is a putative GC box in the cytochrome P450 1A2 (CYP1A2) promoter, its
function has remained undetermined. To understand the molecular mechanisms controlling …
function has remained undetermined. To understand the molecular mechanisms controlling …