Recent advances in genomic technology have led to a better understanding of key
molecular alterations that underlie glioblastoma (GBM). The current WHO-based …

We have extended our understanding of the molecular biology that underlies adult
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …

In preclinical models of glioblastoma, antigen escape variants can lead to tumor recurrence
after treatment with CAR T cells that are redirected to single tumor antigens. Given the …

Time series clustering is an essential unsupervised technique in cases when category
information is not available. It has been widely applied to genome data, anomaly detection …

Summary The Cancer Genome Atlas Network recently cataloged recurrent genomic
abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression …

We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the
context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples …

Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide
substitutions and epigenetic modifications that drive malignant transformation. The Cancer …

Previously undescribed prognostic subclasses of high-grade astrocytoma are identified and
discovered to resemble stages in neurogenesis. One tumor class displaying neuronal …

Malignant astrocytic gliomas such as glioblastoma are the most common and lethal
intracranial tumors. These cancers exhibit a relentless malignant progression characterized …

Malignant brain tumours continue to be the cause of a disproportionate level of morbidity
and mortality across a wide range of individuals. The most common variants in the adult and …