Aging is an inevitable outcome of life, characterized by a progressive decline in tissue and
organ function. At a molecular level, it is marked by the gradual alterations of biomolecules …

Cancer was thought to be caused solely by genetic mutations in oncogenes and tumor
suppressor genes. In the last 35 years, however, epigenetic changes have been …

Background Acute myeloid leukemia (AML) is a common leukemia subtype and has a poor
prognosis. The risk of AML is highly related to age. In the context of population aging, a …

Abstract Aberrant changes in 5-hydroxymethylcytosine (5hmC) are a unique epigenetic
feature in many cancers including acute myeloid leukemia (AML). However, genome-wide …

Mutations of the TP53 gene occur in a subset of patients with acute myeloid leukemia (AML)
and confer an exceedingly adverse prognosis. However, whether different types of TP53 …

Sphingolipids and their metabolic pathways have been implicated in disease development
and therapeutic response; however, the detailed mechanisms remain unclear. Using a …

One of the traits of cancer cells is abnormal DNA methylation patterns. The idea that age-
related epigenetic changes may partially explain the increased risk of cancer in the elderly is …

Aging as an inevitable phenomenon is associated with pervasive changes in physiological
functions. There is a relationship between aging and the increase of several chronic …

Years of important research has revealed that cells heavily invest in regulating their size.
Nevertheless, it has remained unclear why accurate size control is so important. Our recent …

Many patients with acute myeloid leukemia (AML) experience poor outcomes following
traditional high-dose chemotherapies and complete remission rates remain suboptimal …