Cell-type deconvolution from DNA methylation: a review of recent applications
Recent advances in cell-type deconvolution approaches are adding to our understanding of
the biology underlying disease development and progression. DNA methylation (DNAm) …
the biology underlying disease development and progression. DNA methylation (DNAm) …
The emerging role of TXNIP in ischemic and cardiovascular diseases; a novel marker and therapeutic target
A Domingues, J Jolibois, P Marquet de Rougé… - International Journal of …, 2021 - mdpi.com
Thioredoxin interacting protein (TXNIP) is a metabolism-oxidative-and inflammation-related
marker induced in cardiovascular diseases and is believed to represent a possible link …
marker induced in cardiovascular diseases and is believed to represent a possible link …
Association of body mass index with DNA methylation and gene expression in blood cells and relations to cardiometabolic disease: a Mendelian randomization …
Background The link between DNA methylation, obesity, and adiposity-related diseases in
the general population remains uncertain. Methods and Findings We conducted an …
the general population remains uncertain. Methods and Findings We conducted an …
Epigenetic prediction of complex traits and death
Background Genome-wide DNA methylation (DNAm) profiling has allowed for the
development of molecular predictors for a multitude of traits and diseases. Such predictors …
development of molecular predictors for a multitude of traits and diseases. Such predictors …
Association of cardiovascular health through young adulthood with genome-wide DNA methylation patterns in midlife: the CARDIA study
Background: Cardiovascular health (CVH) from young adulthood is strongly associated with
an individual's future risk of cardiovascular disease (CVD) and total mortality. Defining …
an individual's future risk of cardiovascular disease (CVD) and total mortality. Defining …
DNA methylation and obesity traits: An epigenome-wide association study. The REGICOR study
S Sayols-Baixeras, I Subirana, A Fernández-Sanlés… - Epigenetics, 2017 - Taylor & Francis
Obesity is associated with increased risk of several diseases and has become epidemic.
Obesity is highly heritable but the genetic variants identified by genome-wide association …
Obesity is highly heritable but the genetic variants identified by genome-wide association …
[HTML][HTML] Carbohydrate and fat intake associated with risk of metabolic diseases through epigenetics of CPT1A
CQ Lai, LD Parnell, CE Smith, T Guo… - The American journal of …, 2020 - Elsevier
Background Epigenome-wide association studies identified the cg00574958 DNA
methylation site at the carnitine palmitoyltransferase-1A (CPT1A) gene to be associated with …
methylation site at the carnitine palmitoyltransferase-1A (CPT1A) gene to be associated with …
Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence
DNA methylation (DNAm) is known to play a pivotal role in childhood health and
development, but a comprehensive characterization of genome-wide DNAm trajectories …
development, but a comprehensive characterization of genome-wide DNAm trajectories …
[HTML][HTML] Essentiality of SLC7A11-mediated nonessential amino acids in MASLD
Metabolic dysfunction-associated steatotic liver disease (MASLD) remains a rapidly growing
global health burden. Here, we report that the nonessential amino acid (NEAA) transporter …
global health burden. Here, we report that the nonessential amino acid (NEAA) transporter …
Body mass index drives changes in DNA methylation: a longitudinal study
Rationale: Previous EWASs (Epigenome-Wide Association Studies) suggest that obesity
may be the cause, not a consequence, of changes in DNA methylation (DNAm). However …
may be the cause, not a consequence, of changes in DNA methylation (DNAm). However …