Protein stability is a topic of major interest for the biotechnology, pharmaceutical and food
industries, in addition to being a daily consideration for academic researchers studying …

Phage display is achieved by fusing polypeptide libraries to phage coat proteins. The
resulting phage particles display the polypeptides on their surfaces and they also contain …

Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …

Proline is established as a potent breaker of both alpha-helical and beta-sheet structures in
soluble (globular) proteins. Thus, the frequent occurrence of the Pro residue in the putative …

We have investigated the subcellular localization, the domain topology, and the amino acid
residues that are critical for the function of the presumptive Arabidopsis thaliana auxin influx …

Specific helix–helix interactions inside lipid bilayers guide the folding and assembly of many
integral membrane proteins and their complexes. We report here a pattern of 7 amino acids …

The nature and distribution of amino acids in the helix interfaces of four polytopic membrane
proteins (cytochrome c oxidase, bacteriorhodopsin, the photosynthetic reaction center of …

The integral membrane protein diacylglycerol kinase (DGK) from Escherichia coli has been
reversibly unfolded in a protein/detergent/mixed micelle system by varying the molar ratio of …

Membrane proteins can be extremely stable in a bilayer environment, but are often unstable
and rapidly lose activity after detergent solubilization. Poor stability can preclude the …

Specific interactions between membrane spanning polypeptide segments are important for
folding and oligomerisation of integral membrane proteins. Previously the dimerisation of …