Alzheimer's disease is a complex disorder affecting multiple neurotransmitters. In particular,
the degenerative progression is associated with loss within the cholinergic systems. It …

The role of desensitization of ligand-gated channels at fast chemical synapses has been
difficult to establish. Desensitization has been studied traditionally with prolonged agonist …

The influence of α and β subunits on the properties of nicotine-induced activation and
desensitization of neuronal nicotinic acetylcholine receptors (nAChRs) expressed in …

Pentameric ligand‐gated ion channels (pLGICs) mediate fast neurotransmission in the
nervous system. Their dysfunction is associated with psychiatric, neurological and …

The rate constants of acetylcholine receptor channels (AChR) desensitization and recovery
were estimated from the durations and frequencies of clusters of single-channel currents …

The nicotinic acetylcholine (ACh) receptors cycle among classes of nonconducting resting
states, conducting open states, and nonconducting desensitized states. We previously …

The α7-type nicotinic acetylcholine receptor (nAChR) was recently found to be both fully
activated and desensitized by choline, in addition to ACh. In order to understand the …

We describe a maximum likelihood method for direct estimation of rate constants from
macroscopic ion channel data for kinetic models of arbitrary size and topology. The number …

The lifetimes of activated postsynaptic receptor channels contribute to the efficiency of
synaptic transmission. Here we show that structural differences within the interface dividing …

We examined desensitization by acetylcholine (ACh) and nicotine at the rat α4β2 neuronal
nicotinic receptor stably expressed in HEK cells. For both agonists, the decay in response …