Biomarkers of neurodegeneration and neuronal injury have the potential to improve
diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy …

Multiple sclerosis is a highly heterogeneous disease, and the detection of neuroaxonal
damage as well as its quantification is a critical step for patients. Blood-based serum …

Multiple sclerosis (MS) is an autoimmune, inflammatory neurodegenerative disease of the
central nervous system characterized by demyelination and axonal damage. Diagnosis and …

Measurement of serum neurofilament light chain concentration (sNfL) promises to become a
convenient, cost effective and meaningful adjunct for multiple sclerosis (MS) prognostication …

Neurofilament proteins (Nf) have been validated and established as a reliable body fluid
biomarker for neurodegenerative pathology. This review covers seven Nf isoforms, Nf light …

Introduction: Multiple Sclerosis (MS) is the most common immune-mediated chronic
neurodegenerative disease of the central nervous system (CNS) affecting young people …

Objective To determine whether natalizumab efficacy is maintained when switching to
personalized extended interval dosing based on individual natalizumab trough …

Background Progressive multifocal leukoencephalopathy (PML) is a rare and often lethal
brain disorder caused by the common, typically benign polyomavirus 2, also known as JC …

Chronic inflammatory diseases such as rheumatoid arthritis (RA), Juvenile Idiopathic
Arthritis (JIA), psoriasis, and inflammatory bowel disease (IBD) are characterized by …

Objective To investigate the statistical power of plasma, imaging, and cognition biomarkers
as Alzheimer's disease (AD) clinical trial outcome measures. Methods Plasma neurofilament …