The members of the genus Alphavirus are positive-sense RNA viruses, which are
predominantly transmitted to vertebrates by a mosquito vector. Alphavirus disease in …

In this review, we summarize the current knowledge about the membranous replication
factories of members of plus-strand (+) RNA viruses. We discuss primarily the architecture of …

Severe acute respiratory syndrome coronavirus (SARS-CoV), a newly identified group 2
coronavirus, is the causative agent of severe acute respiratory syndrome, a life-threatening …

Plus-strand RNA virus replication occurs in tight association with cytoplasmic host cell
membranes. Both, viral and cellular factors cooperatively generate distinct organelle-like …

All plus-strand RNA viruses replicate in association with cytoplasmic membranes of infected
cells. The RNA replication complex of many virus families is associated with the …

The Golgi apparatus is the central hub for protein trafficking and glycosylation in the
secretory pathway. However, how the Golgi responds to glucose deprivation is so far …

Viruses are divided into seven classes on the basis of differing strategies for storing and
replicating their genomes through RNA and/or DNA intermediates. Despite major …

Alphaviruses cause debilitating disease in humans and animals and are transmitted by
blood-feeding arthropods, typically mosquitoes. With a traditional focus on two models …

Alphaviruses are typically arthropod-borne, and many are important pathogens such as
chikungunya virus. Alphaviruses encode four nonstructural proteins (nsP1–4), initially …

Alphaviruses are small, enveloped viruses,~ 70 nm in diameter, containing a single‐
stranded, positive‐sense, RNA genome. Viruses belonging to this genus are predominantly …