Transition-metal-catalyzed, coordination-assisted C (sp3)–H functionalization has
revolutionized synthetic planning over the past few decades as the use of these directing …

Transition-metal-catalyzed C–H activation has developed a contemporary approach to the
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …

This Review summarizes the advancements in Pd-catalyzed C (sp3)–H activation via
various redox manifolds, including Pd (0)/Pd (II), Pd (II)/Pd (IV), and Pd (II)/Pd (0). While few …

The functionalization of C (sp3)− H bonds streamlines chemical synthesis by allowing the
use of simple molecules and providing novel synthetic disconnections. Intensive recent …

Biaryl scaffolds are found in natural products and drug molecules and exhibit a wide range
of biological activities. In past decade, the transition metal-catalyzed C–H arylation reaction …

Differentiating between two highly similar C–H bonds in a given molecule remains a
fundamental challenge in synthetic organic chemistry. Directing group assisted strategies for …

An isolated Csingle bondH bond in a molecule has a very low reactivity owing to the large
kinetic barrier associated to the Csingle bondH bond cleavage and the apolar nature of this …

A method for direct cross coupling between unactivated C (sp3)–H bonds and
chloroformates has been accomplished via nickel and photoredox catalysis. A diverse range …

Site selectivity and stereocontrol remain major challenges in C–H bond functionalization
chemistry, especially in linear aliphatic saturated hydrocarbon scaffolds. We report the …

L, X-Type transient directing groups (TDGs) based on a reversible imine linkage have
emerged as broadly useful tools for C–H activation of ketones and free amines. However …