Ubiquitin-conjugating enzymes (E2s) are the central players in the trio of enzymes
responsible for the attachment of ubiquitin (Ub) to cellular proteins. Humans have∼ 40 E2s …

The ubiquitin/proteasome system is a primary conduit for selective intracellular protein
degradation. Since its discovery over 30 years ago, this highly regulated system continues to …

BRCA1/2 proteins function in genome stability by promoting repair of double-stranded DNA
breaks through homologous recombination and by protecting stalled replication forks from …

Dendritic cells (DCs) are indispensable for defense against pathogens but may also
contribute to immunopathology. Activation of DCs upon the sensing of pathogens by Toll-like …

Ubc13 is an ubiquitin E2 conjugating enzyme that participates with many different E3 ligases
to form lysine 63-linked (Lys63) ubiquitin chains that are critical to signaling in inflammatory …

Abstract Development of effective cancer therapeutic strategies relies on our ability to
interfere with cellular processes that are dysregulated in tumors. Given the essential role of …

Dysregulation of innate immune signaling pathways is implicated in various hematologic
malignancies. However, these pathways have not been systematically examined in acute …

In the past two decades, drug candidates with a covalent binding mode have gained the
interest of medicinal chemists, as several covalent anticancer drugs have successfully …

Ubiquitination is a multi-step enzymatic process that involves the marking of a substrate
protein by bonding a ubiquitin and protein for proteolytic degradation mainly via the ubiquitin …

Abstract UBE2N is a K63-specific ubiquitin conjugase linked to various immune disorders
and cancer. Here, we demonstrate that UBE2N and its partners UBE2V1 and UBE2V2 are …