Abstract N 6-Methyladenosine (m6A), the most abundant internal modification associated
with eukaryotic mRNAs, has emerged as a dynamic regulatory mechanism controlling the …

First identified in 1974, m 6 A RNA methylation, which serves as a predominant internal
modification of RNA in higher eukaryotes, has gained prodigious interest in recent years …

Summary N 6-Methyladenosine (m 6 A) represents the most prevalent internal modification
in mammalian mRNAs. Despite its functional importance in various fundamental …

The concept of differentiation therapy emerged from the fact that hormones or cytokines may
promote differentiation ex vivo, thereby irreversibly changing the phenotype of cancer cells …

Retinoic acid (RA) is a morphogen derived from retinol (vitamin A) that plays important roles
in cell growth, differentiation, and organogenesis. The production of RA from retinol requires …

Despite its many therapeutic qualities, arsenic trioxide has been more commonly
remembered as Madame Bovary's poison than as an anticancer drug. The ability of arsenic …

A key issue in the immune system is to generate specific cell types, often with opposing
activities. The mechanisms of differentiation and subtype specification of immune cells such …

We have produced Csf1r-deficient rats by homologous recombination in embryonic stem
cells. Consistent with the role of Csf1r in macrophage differentiation, there was a loss of …

Pediatric acute myeloid leukemia (pAML) is characterized by heterogeneous cellular
composition, driver alterations and prognosis. Characterization of this heterogeneity and …

The ability to prevent radiotherapy-induced toxicity without affecting antitumor efficacy has
the potential to enhance the therapeutic benefit for cancer patients without increasing their …