The role of adipokines in health and disease

VJ Clemente-Suárez, L Redondo-Flórez… - Biomedicines, 2023 - mdpi.com
Adipokines are cell-signaling proteins secreted by adipose tissue that has been related to a
low-grade state of inflammation and different pathologies. The present review aims to …

Recent advances in the knowledge of the mechanisms of leptin physiology and actions in neurological and metabolic pathologies

ME Casado, R Collado-Pérez, LM Frago… - International Journal of …, 2023 - mdpi.com
Excess body weight is frequently associated with low-grade inflammation. Evidence
indicates a relationship between obesity and cancer, as well as with other diseases, such as …

[HTML][HTML] The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives

AB Behrooz, M Cordani, A Fiore, M Donadelli… - Seminars in Cancer …, 2024 - Elsevier
Autophagy, a self-degradative process vital for cellular homeostasis, plays a significant role
in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex …

Regulation of mitochondrial metabolism by autophagy supports leptin-induced cell migration

A García-Miranda, JB Montes-Alvarado… - Scientific Reports, 2024 - nature.com
Leptin is an adipokine secreted by adipose tissue, which promotes tumor progression by
activating canonical signaling pathways such as MAPK/ERK. Recent studies have shown …

Effects of obesity and calorie restriction on cancer development

E Sergeeva, T Ruksha, Y Fefelova - International Journal of Molecular …, 2023 - mdpi.com
The risk of malignant tumor development is increasing in the world. Obesity is an
established risk factor for various malignancies. There are many metabolic alterations …

Adipo-oncology: adipocyte-derived factors govern engraftment, survival, and progression of metastatic cancers

S Sato - Cell Communication and Signaling, 2024 - Springer
Conventional therapies for metastatic cancers have limited efficacy. Recently, cancer
therapies targeting noncancerous cells in tumor microenvironments have shown improved …

[PDF][PDF] Adiponectin mRNA Conjugated with Lipid Nanoparticles Specifically Targets the Pathogenesis of Type 2 Diabetes

RE El-Araby, Q Tu, Y Xie, T Aboushousha, Z Li… - Aging and …, 2025 - researchgate.net
Type 2 diabetes (T2D) is a widespread health condition both in the United States and
around the world, with insulin resistance playing a critical role in its development. Effective …

Влияние ожирения на формирование и развитие рака

СВ Мустафина, ДА Винтер… - Ожирение и …, 2024 - omet-endojournals.ru
Аннотация В настоящее время убедительно показано, что избыточная масса тела и
ожирение ассоциированы с развитием не менее 13 видов рака, включая рак молочной …

The Obesity Epidemic and Cancer Risk: Molecular Pathways, Risk Factors and Therapeutic Avenues

HQ Sadida, A Abdulla, AM Varghese, M Algahdary… - 2024 - Springer
Obesity, characterized by the excessive and abnormal accumulation of body fat, has been
classified as a global pandemic by the World Health Organization (WHO). This is an …

Prognostički značaj Serumskog Adiponektina u B-ćelijskim Limfoproliferativnim Bolestima

N Vlaisavljević - 2023 - search.proquest.com
UVOD: Predmet ovog istraživanja su B limfoproliferativne bolesti i to difuzni krupnoćelijski B
limfom (predstavnik agresivne forme nehočkinskih limfoma), folikularni limfom (predstavnik …