Youden's test is a reliable method to evaluate the robustness of analytical methods, by
means of an experiment design which involves seven analytical parameters combined in …

The oral absorption of compounds with low aqueous solubility, such as lumefantrine, is
typically limited by the dissolution rate in the gastro-intestinal tract, resulting in erratic …

Diosgenin is an important precursor of semi-synthetic steroids such as corticosteroids, sex
hormones (eg, progesterone) and other steroidal drugs in pharmaceutical industry (Oncina …

Introduction: Malaria, an infectious disease caused by protozoa of the genus Plasmodium, is
highly prevalent in the Brazilian Amazon. Chloroquine is the first-choice drug for the …

Background β-glucosidase is an enzyme important to flavour enhancement. It hydrolyzes
glucosides to release aglycones—aroma precursors that are bound to a sugar molecule …

Background Artemisinin-based fixed dose combination (FDC) products are recommended
by World Health Organization (WHO) as a first-line treatment. However, the current …

Background & objectives: The artemisinin-based antimalarial medicines are first line
medicines in the treatment of severe and uncomplicated falciparum malaria. Numerous …

Background Lumefantrine (benflumetol) is a fluorene derivative belonging to the aryl amino
alcohol class of anti-malarial drugs and is commercially available in fixed combination …

A simple, rapid, precise and accurate reversed phase high performance liquid
chromatographic method has been developed for the simultaneous determination of …

ABSTRACT A Simple, sensitive, specific, spectrophotometric method has been developed
for the detection of Lumefantrine in pure form and Pharmaceutical formulations. The …