Antioxidant enzymes form the first line of defense against free radicals in organisms. Their
regulation depends mainly on the oxidant status of the cell, given that oxidants are their …

The gastrointestinal tract of vertebrate species is a rich source of extrapineal melatonin. The
concentration of melatonin in the gastrointestinal tissues surpasses blood levels by 10–100 …

Melatonin has been shown to protect against oxidative stress in various, highly divergent
experimental systems. There are many reasons for its remarkable protective potential …

Ischemia—Reperfusion injury of the intestine is a significant problem in abdominal aortic
aneurysm surgery, small bowel transplantation, cardiopulmonary bypass, strangulated …

Recent data from several reports indicate that free radicals are involved in
aetiopathogenesis of many human pathologies including neuropsychiatric disorders such as …

Melatonin, originally discovered as a hormone of the pineal gland, is also produced in other
organs and represents, additionally, a normal food constituent found in yeast and plant …

Exacerbation of hypoxic injury after reoxygenation is a crucial mechanism mediating organ
injury in transplantation, and in myocardial, hepatic, gastrointestinal, cerebral, renal, and …

Melatonin (MEL) shows an anti-inflammatory effect and regulates intestinal microbiota
communities in animals and humans; Ochratoxin A (OTA) induces liver inflammation through …

抄録 Intestinal ischemia/reperfusion injury is a severe disease associated with a high
mortality. The mechanisms that cause ischemia/reperfusion injury are complex and many …

Introduction Intestinal diseases, a leading global cause of mortality and morbidity, carry a
substantial socioeconomic burden. Small and large intestines play pivotal roles in …