Systemic mastocytosis is a heterogeneous disease characterized by the accumulation of
neoplastic mast cells in the bone marrow and other organ organs/tissues. Mutations in KIT …

Mast cells (MCs) are multifunctional immune cells derived from hematopoietic stem cell
(HSC) in the bone marrow (BM). Committed BM MC progenitors (MCPs) are released into …

Individual DNA molecules can be read at single nucleotide precision using nanopores
coupled to processive enzymes. Discrimination among the four canonical bases has been …

Although epigenetic modulation is critical for a variety of cellular activities, its role in
erythropoiesis remains poorly understood. Ten-eleven translocation (TET) molecules …

Epigenetics is the study of inherited changes in phenotype or gene expression that do not
alter DNA sequence. Recently, scientists have focused their attention on 5 …

Simple Summary Systemic mastocytosis (SM) is a clonal haematopoietic stem cell disease
typically characterized by the expansion and accumulation of neoplastic mast cells carrying …

Chromosomal abnormalities provide clinical utility in the diagnosis and treatment of
hematologic malignancies, and may be predictive of malignant transformation in individuals …

Cancer is the result of a multistep process, including various genetic and epigenetic
alterations, such as structural variants, transcriptional factors, telomere length, DNA …

Ten-eleven translocation 2 (TET2) functions as a methylcytosine dioxygenase that catalyzes
the iterative oxidation of 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and …

Hematopoietic stem cells (HSCs) are quiescent cells with self‐renewal capacity and
potential multilineage development. Various molecular regulatory mechanisms such as …