Hormone rhythms are ubiquitous and essential to sustain normal physiological functions.
Combined mathematical modelling and experimental approaches have shown that these …

Over the past decade, there has been an unprecedented international focus on improved
quality and availability of medical care, which has reignited interest in clinical automation …

Glucose control, glucose variability (GV), and risk for hypoglycemia are intimately related,
and it is now evident that GV is important in both the physiology and pathophysiology of …

Predicting glucose values on the basis of insulin and food intakes is a difficult task that
people with diabetes need to do daily. This is necessary as it is important to maintain …

Objective: Type-1 diabetes (T1D) treatment requires exogenous insulin administrations
finely tuned based on glucose monitoring to avoid hyper/hypoglycemia. The safety and …

A new glucose-insulin model is introduced which fits with the clinical data from in-and
outpatients for two days. Its stability property is consistent with the glycemia behavior for type …

Patients affected by type 1 diabetes (T1D) suffer from lack of insulin secretion by the
pancreas, due to the autoimmune destruction of the insulinproducing beta cells. This …

Objective The glucose tolerance test (GTT) is widely used in human and animal biomedical
and pharmaceutical research. Despite its prevalent use, particularly in mouse metabolic …

In this work, the problem of regulating blood glucose (glycemia) in type I diabetic patients is
studied by means of an impulsive zone model predictive control (iZMPC), which bases its …

Hepatic insulin resistance is a major risk factor for the development of type 2 diabetes and is
associated with the accumulation of lipids, including diacylglycerol (DAG), triacylglycerols …