Metal-dependent histone deacetylases (HDACs) catalyze the hydrolysis of acetyl-l-lysine
side chains in histone and nonhistone proteins to yield l-lysine and acetate. This chemistry …

Covering: July 2007 to June 2010. Previous review: Nat. Prod. Rep., 2009, 26, 382–445 A
great number of structurally diverse natural products containing five-membered heterocyclic …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Despite recent success in computational design of structured cyclic peptides, de novo
design of cyclic peptides that bind to any protein functional site remains difficult. To address …

Thiazoles, oxazole and their corresponding reduced derivatives, thiazolines and oxazolines,
are found in marine sources exhibiting significant biological activities. The isolation …

Covering up to 2011 The cyclic depsipeptide largazole from a cyanobacterium of the genus
Symploca is a marine natural product with a novel chemical scaffold and potently inhibits …

Natural products (NPs) have played a key role in drug discovery and are still a prolific
source of novel lead compounds or pharmacophores for medicinal chemistry …

This Review is devoted to the chemistry of macrocyclic peptides having heterocyclic
fragments in their structure. These motifs are present in many natural products and synthetic …

Induction of EBV lytic-phase gene expression, combined with exposure to an antiherpes
viral drug, represents a promising targeted therapeutic approach to EBV-associated …

The systematic modification of natural products through diverted total synthesis is a powerful
concept for the systematic modification of natural products with the aim of studying …