Metabolomic epidemiology offers insights into disease aetiology

H Fuller, Y Zhu, J Nicholas, HA Chatelaine… - Nature …, 2023 - nature.com
Metabolomic epidemiology is the high-throughput study of the relationship between
metabolites and health-related traits. This emerging and rapidly growing field has improved …

What have metabolomics approaches taught us about type 2 diabetes?

A Gonzalez-Franquesa, AM Burkart, E Isganaitis… - Current diabetes …, 2016 - Springer
Abstract Type 2 diabetes (T2D) is increasing worldwide, making identification of biomarkers
for detection, staging, and effective prevention strategies an especially critical scientific and …

Metabolomics of human amniotic fluid and maternal plasma during normal pregnancy

M Orczyk-Pawilowicz, E Jawien, S Deja, L Hirnle… - PloS one, 2016 - journals.plos.org
Metabolic profiles of amniotic fluid and maternal blood are sources of valuable information
about fetus development and can be potentially useful in diagnosis of pregnancy disorders …

Rapid and reliable identification of phospholipids for untargeted metabolomics with LC–ESI–QTOF–MS/MS

J Godzien, M Ciborowski… - Journal of Proteome …, 2015 - ACS Publications
Lipids are important components of biological systems, and their role can be currently
investigated by the application of untargeted, holistic approaches such as metabolomics and …

MALDI-MS imaging reveals asymmetric spatial distribution of lipid metabolites from bisphenol S-induced nephrotoxicity

C Zhao, P Xie, T Yong, H Wang, ACK Chung… - Analytical …, 2018 - ACS Publications
With the continuous exposure of environmental pollutants in organisms, determination of
abundance variation and spatial distribution of lipids might expand our understanding of …

Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries

R Kadakia, M Nodzenski, O Talbot, A Kuang, JR Bain… - Diabetologia, 2019 - Springer
Aims/hypothesis We aimed to determine the association of maternal metabolites with
newborn adiposity and hyperinsulinaemia in a multi-ethnic cohort of mother–newborn …

Adipokines in pregnancy: A systematic review of clinical data

N Kabbani, M Blüher, H Stepan, M Stumvoll, T Ebert… - Biomedicines, 2023 - mdpi.com
Adipokines are signaling proteins involved in metabolic, endocrinological, vascular and
immunogenic processes. Associations of various adipokines with not only insulin resistance …

Altered triglyceride and phospholipid metabolism predates the diagnosis of gestational diabetes in obese pregnancy

S Furse, SL White, CL Meek, B Jenkins, CJ Petry… - Molecular omics, 2019 - pubs.rsc.org
Gestational diabetes (GDM), a common pregnancy complication associated with obesity and
long-term health risks, is usually diagnosed at approximately 28 weeks of gestation. An …

Maternal body mass index, early-pregnancy metabolite profile, and birthweight

RJ Wahab, VWV Jaddoe, E Voerman… - The Journal of …, 2022 - academic.oup.com
Context Maternal prepregnancy body mass index (BMI) has a strong influence on
gestational metabolism, but detailed metabolic alterations are unknown. Objective First, to …

Metabolome wide association study of serum poly and perfluoroalkyl substances (PFASs) in pregnancy and early postpartum

X Hu, S Li, PM Cirillo, NY Krigbaum, VL Tran… - Reproductive …, 2019 - Elsevier
High-resolution metabolomics (HRM) profiling of metabolic fingerprints can improve
understanding of how poly and perfluoroalkyl substances (PFASs) induce metabolic …