The theory is advanced that the common denominator of a wide range of addictive
substances is their ability to cause psychomotor activation. This view is related to the theory …

Although opioids are highly effective for the treatment of pain, they are also known to be
intensely addictive. There has been a massive research investment in the development of …

Studies of the brain mechanisms of addictive drug actions suggest a two-factor model of
addiction. First, all addictive substances are argued to have psychomotor stimulant …

Recently, we demonstrated that delta opioid binding sites are Involved in the development of
morphine tolerance and dependence. In our present work, we studied the effect of the potent …

In order to determine the relationship between endorphins and social attachment, the effects
of morphine (an opiate agonist) and naloxone (an opiate antagonist) on various indices of …

The opiate-like peptide β-endorphin and adrenocorticotropin are concomitantly secreted in
increased amounts by the adenohypophysis in response to acute stress or long-term …

Great progress in the understanding of the mechanisms by which drugs influence behavior
has resulted from recent studies of the binding of drugs to receptors. While not all drugs …

If the entire materia medica at our disposal were limited to the choice and use of only one
drug, I am sure that a great many, if not the majority, of us would choose opium (Macht …

The premenstrual syndrome (PMS) is a major clinical entity afflicting a large segment of the
female population. Available information are descriptive in nature and the etiology of this …

Opiates appear to have rewarding actions at more than one locus in the brain. Studies of the
effects of dopaminergic lesions and dopamine receptor blockade indicate that intravenous …