Chemistry, biosynthesis and pharmacology of streptonigrin: an old molecule with future prospects for new drug design, development and therapy
N Nabihah Nasir, M Sekar, S Ravi… - Drug Design …, 2023 - Taylor & Francis
Streptonigrin is an aminoquinone alkaloid isolated from Streptomyces flocculus and is
gaining attention as a drug molecule owing to its potential antitumor and antibiotic effects. It …
gaining attention as a drug molecule owing to its potential antitumor and antibiotic effects. It …
Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors
Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent
members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or …
members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or …
Design, synthesis, and biological evaluation of novel 1, 3, 4-thiadiazole derivatives as potential antitumor agents against chronic myelogenous leukemia: Striking …
In an attempt to develop potent antitumor agents, new 1, 3, 4-thiadiazole derivatives were
synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines …
synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines …
Synthesis, biological properties, and acid dissociation constant of novel naphthoquinone–triazole hybrids
Abstract A series of novel 1, 4-naphthoquinone–triazole hybrids, N-(3-amino-1, 4-dioxo-1, 4-
dihydronaphthalen-2-yl)-2-(4-R-1H-1, 2, 3-triazol-1-yl) acetamide, was synthesized by click …
dihydronaphthalen-2-yl)-2-(4-R-1H-1, 2, 3-triazol-1-yl) acetamide, was synthesized by click …
Design, synthesis, and biological activity of Plastoquinone analogs as a new class of anticancer agents
In this paper, based on Plastoquinone (PQ) analogs possessing substituted aniline
containing alkoxy group (s), new 2, 3-dimethyl-5-amino-1, 4-benzoquinones (PQ1-15) were …
containing alkoxy group (s), new 2, 3-dimethyl-5-amino-1, 4-benzoquinones (PQ1-15) were …
Design, synthesis and biological evaluation of pentacyclic triterpene derivatives: Optimization of anti-ABL kinase activity
H I. Ciftci, M O. Radwan, S E. Ozturk, NG Ulusoy… - Molecules, 2019 - mdpi.com
Imatinib, an Abelson (ABL) tyrosine kinase inhibitor, is a lead molecular-targeted drug
against chronic myelogenous leukemia (CML). To overcome its resistance and adverse …
against chronic myelogenous leukemia (CML). To overcome its resistance and adverse …
Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement
S-trityl-l-cysteine (STLC) is a well-recognized lead compound known for its anticancer
activity owing to its potent inhibitory effect on human mitotic kinesin Eg5. STLC contains two …
activity owing to its potent inhibitory effect on human mitotic kinesin Eg5. STLC contains two …
A novel series of chlorinated plastoquinone analogs: Design, synthesis, and evaluation of anticancer activity
Herein, we report the synthesis and cytotoxic effects of novel chlorinated plastoquinone
analogs (ABQ1–17) against different leukemic cells. Compounds ABQ3, ABQ11, and ABQ12 …
analogs (ABQ1–17) against different leukemic cells. Compounds ABQ3, ABQ11, and ABQ12 …
An expeditious and green one-pot synthesis of 12-substituted-3,3-dimethyl-3,4,5,12-tetrahydrobenzo[b]acridine-1,6,11(2H)-triones
S Kamalifar, H Kiyani - Research on Chemical Intermediates, 2019 - Springer
In this study, several new 12-aryl/heteroaryl-3, 3-dimethyl-tetrahydrobenzo [b] acridine-1, 6,
11 (2 H)-trione heterocyclic compounds that can be considered as 1, 4-naphthoquinone …
11 (2 H)-trione heterocyclic compounds that can be considered as 1, 4-naphthoquinone …
Investigation of the antimicrobial and anticancer activity of aminonaphthoquinones
KW Wellington, NI Kolesnikova… - Drug Development …, 2019 - Wiley Online Library
In this study, we report on the inhibitory activity of synthesized aminonaphthoquinones
against two bacterial and one fungal species to determine their antimicrobial properties. A …
against two bacterial and one fungal species to determine their antimicrobial properties. A …