Sorting through the extensive and confusing roles of sortilin in metabolic disease
Sortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting
receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure …
receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure …
The emerging landscape of peptide-based inhibitors of PCSK9
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a clinically validated target for
treating cardiovascular disease (CVD) due to its involvement in cholesterol metabolism …
treating cardiovascular disease (CVD) due to its involvement in cholesterol metabolism …
Sortilin drives hypertension by modulating sphingolipid/ceramide homeostasis and by triggering oxidative stress
F Varzideh, SS Jankauskas… - The Journal of …, 2022 - Am Soc Clin Investig
Sortilin is a glycoprotein mainly known for its role as a trafficking molecule directing proteins
to specific secretory or endocytic compartments of the cell. Its actual contribution to essential …
to specific secretory or endocytic compartments of the cell. Its actual contribution to essential …
VLDL Biogenesis and Secretion: it takes a village
W Van Zwol, B Van De Sluis, HN Ginsberg… - Circulation …, 2024 - Am Heart Assoc
The production and secretion of VLDLs (very-low-density lipoproteins) by hepatocytes has a
direct impact on liver fat content, as well as the concentrations of cholesterol and …
direct impact on liver fat content, as well as the concentrations of cholesterol and …
Insights Into PCSK9-LDLR Regulation and Trafficking Via the Differential Functions of MHC-I Proteins HFE and HLA-C
S Mikaeeli, A Ben Djoudi Ouadda, A Evagelidis… - Cells, 2024 - mdpi.com
PCSK9 is implicated in familial hypercholesterolemia via targeting the cell surface PCSK9-
LDLR complex toward lysosomal degradation. The M2 repeat in the PCSK9's C-terminal …
LDLR complex toward lysosomal degradation. The M2 repeat in the PCSK9's C-terminal …
Sortilin and hypertension
R Avvisato, SS Jankauskas, F Varzideh… - Current opinion in …, 2023 - journals.lww.com
Sortilin and hypertension : Current Opinion in Nephrology and Hypertension Sortilin and
hypertension : Current Opinion in Nephrology and Hypertension Log in or Register Subscribe to …
hypertension : Current Opinion in Nephrology and Hypertension Log in or Register Subscribe to …
Chemically‐Induced Lipoprotein Breakdown for Improved Extracellular Vesicle Purification
Extracellular vesicles (EVs) are nanosized biomolecular packages involved in intercellular
communication. EVs are released by all cells, making them broadly applicable as …
communication. EVs are released by all cells, making them broadly applicable as …
Sortilin is dispensable for secondary injury processes following traumatic brain injury in mice
I Staib-Lasarzik, C Gölz, W Bobkiewiecz, P Somnuke… - Heliyon, 2024 - cell.com
Traumatic brain injury (TBI) is characterized by complex secondary injury processes
involving the p75 neurotrophin receptor (p75NTR), which has been proposed as a possible …
involving the p75 neurotrophin receptor (p75NTR), which has been proposed as a possible …
[HTML][HTML] Sortilin 蛋白在脂质代谢中的研究进展
初星霖， 刘瑞， 柯大智 - Advances in Clinical Medicine, 2022 - hanspub.org
血脂异常是导致各种心血管代谢疾病的重要危险因素, 严重影响人类健康. Sortilin
作为液泡分拣因子10 结构域受体家族的一员, 充当细胞的受体或共同受体 …
作为液泡分拣因子10 结构域受体家族的一员, 充当细胞的受体或共同受体 …
Missense variants in SORT1 are associated with LDL-C in an Amish population
KA Mitok, KL Schueler, SM King, J Orr, KA Ryan… - Journal of Lipid …, 2023 - ASBMB
Common noncoding variants at the human 1p13. 3 locus associated with SORT1 expression
are among those most strongly associated with low-density lipoprotein cholesterol (LDL-C) …
are among those most strongly associated with low-density lipoprotein cholesterol (LDL-C) …