Potent acetylcholinesterase inhibitors: potential drugs for Alzheimer's disease

H Akıncıoğlu, İ Gülçin - Mini reviews in medicinal chemistry, 2020 - ingentaconnect.com
Alzheimer's disease (AD) is one of the cognitive or memory-related impairments occurring
with advancing age. Since its exact mechanism is not known, the full therapy has still not …

Sulfonamide inhibitors: a patent review 2013-present

İ Gulçin, P Taslimi - Expert opinion on therapeutic patents, 2018 - Taylor & Francis
Introduction: Sulfonamide compounds are significant class of synthetic bacteriostatic
antibiotics still which used today for the therapy of bacterial infections and those caused by …

Discovery of sulfadrug–pyrrole conjugates as carbonic anhydrase and acetylcholinesterase inhibitors

M Gümüş, ŞN Babacan, Y Demir, Y Sert… - Archiv Der …, 2022 - Wiley Online Library
Human carbonic anhydrase (hCA) isoenzymes are zinc ion‐containing, widespread
metalloenzymes and they classically play a role in pH homeostasis maintenance. CA …

Comprehensive Metabolite Profiling of Cinnamon (Cinnamomum zeylanicum) Leaf Oil Using LC-HR/MS, GC/MS, and GC-FID: Determination of Antiglaucoma …

M Mutlu, Z Bingol, EM Uc, E Köksal, AC Goren… - Life, 2023 - mdpi.com
In this study, for the first time, the antioxidant and antidiabetic properties of the essential oil
from cinnamon (Cinnamomum zeylanicum) leaves were evaluated and investigated using …

Synthesis and biological evaluation of novel tris-chalcones as potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α-glycosidase inhibitors

S Burmaoglu, AO Yilmaz, MF Polat, R Kaya, İ Gulcin… - Bioorganic …, 2019 - Elsevier
A novel class of fluoro-substituted tris-chalcones derivatives (5a-5i) was synthesized from
phloroglucinol and corresponding benzaldehydes. A three step synthesis method was …

LC–MS/MS analysis, antioxidant and anticholinergic properties of galanga (Alpinia officinarum Hance) rhizomes

LP Köse, I Gülcin, AC Gören, J Namiesnik… - Industrial crops and …, 2015 - Elsevier
Abstract Galanga (Alpinia officinarum Hance) is a pungent and aromatic rhizome, which is a
member of the ginger family (Zingiberaceae). The rhizomes of this plant have been used as …

Isofraxidin: Antioxidant, Anti‐carbonic Anhydrase, Anti‐cholinesterase, Anti‐diabetic, and in Silico Properties

L Durmaz, İ Gulçin, P Taslimi, B Tüzün - ChemistrySelect, 2023 - Wiley Online Library
The development of innovative pharmacological formulations for the treatment and
prevention of various major diseases, including cancer, diabetes, and glaucoma, has been …

Rosmarinic acid inhibits some metabolic enzymes including glutathione S-transferase, lactoperoxidase, acetylcholinesterase, butyrylcholinesterase and carbonic …

İ Gülçin, A Scozzafava, CT Supuran… - Journal of enzyme …, 2016 - Taylor & Francis
Rosmarinic acid (RA) is a natural polyphenol contained in many aromatic plants with
promising biological activities. Carbonic anhydrases (CAs, EC 4.2. 1.1) are widespread and …

Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes

K Kucukoglu, HI Gul, P Taslimi, I Gulcin… - Bioorganic chemistry, 2019 - Elsevier
Recently, inhibition of carbonic anhydrase (hCA) and acetylcholinesterase (AChE) have
appeared as a promising approach for pharmacological intervention in a variety of disorders …

Antioxidant and acetylcholinesterase inhibition properties of novel bromophenol derivatives

N Öztaşkın, Y Çetinkaya, P Taslimi, S Göksu… - Bioorganic chemistry, 2015 - Elsevier
In this study, series of novel bromophenol derivatives were synthesized and investigated for
their antioxidant and AChE inhibition properties. Novel brominated diarylmethanones were …