Halfway between 2D and animal models: are 3D cultures the ideal tool to study cancer-microenvironment interactions?
An area that has come to be of tremendous interest in tumor research in the last decade is
the role of the microenvironment in the biology of neoplastic diseases. The tumor …
the role of the microenvironment in the biology of neoplastic diseases. The tumor …
Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture
A cell spheroid is a three-dimensional (3D) aggregation of cells. Synthetic, in-vitro spheroids
provide similar metabolism, proliferation, and species concentration gradients to those found …
provide similar metabolism, proliferation, and species concentration gradients to those found …
Biomimetic O2-Evolving metal-organic framework nanoplatform for highly efficient photodynamic therapy against hypoxic tumor
Improving the supply of O 2 and the circulation lifetime of photosensitizers for photodynamic
therapy (PDT) in vivo would be a promising approach to eliminate hypoxic tumors. Herein …
therapy (PDT) in vivo would be a promising approach to eliminate hypoxic tumors. Herein …
Drug testing and flow cytometry analysis on a large number of uniform sized tumor spheroids using a microfluidic device
Abstract Three-dimensional (3D) tumor spheroid possesses great potential as an in vitro
model to improve predictive capacity for pre-clinical drug testing. In this paper, we combine …
model to improve predictive capacity for pre-clinical drug testing. In this paper, we combine …
Engineered microsystems for spheroid and organoid studies
Abstract 3D in vitro model systems such as spheroids and organoids provide an opportunity
to extend the physiological understanding using recapitulated tissues that mimic …
to extend the physiological understanding using recapitulated tissues that mimic …
[HTML][HTML] Using spheroids as building blocks towards 3D bioprinting of tumor microenvironment
Cancer still ranks as a leading cause of mortality worldwide. Although considerable efforts
have been dedicated to anticancer therapeutics, progress is still slow, partially due to the …
have been dedicated to anticancer therapeutics, progress is still slow, partially due to the …
A novel 3D breast-cancer-on-chip platform for therapeutic evaluation of drug delivery systems
Y Chen, D Gao, Y Wang, S Lin, Y Jiang - Analytica chimica acta, 2018 - Elsevier
The ability to rapidly screen drugs and drug delivery systems with a more accurate tumor
model to better predict their in vivo performance is of great importance in drug development …
model to better predict their in vivo performance is of great importance in drug development …
A microfluidic spheroid culture device with a concentration gradient generator for high-throughput screening of drug efficacy
Three-dimensional (3D) cell culture is considered more clinically relevant in mimicking the
structural and physiological conditions of tumors in vivo compared to two-dimensional cell …
structural and physiological conditions of tumors in vivo compared to two-dimensional cell …
Photodynamic therapy improves the clinical efficacy of advanced colorectal cancer and recruits immune cells into the tumor immune microenvironment
B Gu, B Wang, X Li, Z Feng, C Ma, L Gao, Y Yu… - Frontiers in …, 2022 - frontiersin.org
Objective Although photodynamic therapy (PDT) has been proven effective in various
tumors, it has not been widely used as a routine treatment for colorectal cancer (CRC), and …
tumors, it has not been widely used as a routine treatment for colorectal cancer (CRC), and …
The current landscape of 3D in vitro tumor models: what cancer hallmarks are accessible for drug discovery?
D Rodenhizer, T Dean, E D'Arcangelo… - Advanced …, 2018 - Wiley Online Library
Cancer prognosis remains a lottery dependent on cancer type, disease stage at diagnosis,
and personal genetics. While investment in research is at an all‐time high, new drugs are …
and personal genetics. While investment in research is at an all‐time high, new drugs are …