Targeting the lung tumor microenvironment by phytochemicals and their nanoformulations

SO Rab, FMA Altalbawy, M Chandra, IA Ariffin… - … -Research and Practice, 2024 - Elsevier
Lung malignancies are among the most prevalent and foremost causes of tumor-related
deaths. Despite significant advancements in the understanding and management of lung …

Traditional Uses, Active Ingredients, and Biological Activities of Paris polyphylla Smith: A Comprehensive Review of an Important Himalayan Medicinal Plant

JM Rawat, S Pandey, B Rawat, N Rai… - Journal of …, 2023 - Wiley Online Library
Paris polyphylla Smith (family: Melanthiaceae), a high‐value medicinal herb endemic to the
Himalayan region, has drawn much attention recently due to its immense use in the …

Ultrasonic-assisted extraction-synergistic deep eutectic solvents for green and efficient incremental extraction of Paris polyphylla saponins

JZ Liu, ZX Lin, WH Kong, CC Zhang, Q Yuan… - Journal of Molecular …, 2022 - Elsevier
Abstract Traditional Chinese medicine Paris polyphylla contains a multitude of bioactive
chemicals, primarily saponins, that have been employed in the pharmaceutical sector for …

A review: the structures and bioactivities of steroidal saponins from Allium macrostemon Bulbus

H Xie, X Shi, D Zhao, B Wang, Y Jin, X Li - Phytochemistry Letters, 2023 - Elsevier
Abstract Allium macrostemon Bulbus (Xiebai in Chinese), as an important medicinal and
edible homologous plant, has two kinds of original plants (the dry bulbs of Allium …

Advances in antitumor activity and mechanism of natural steroidal saponins: A review of advances, challenges, and future prospects

F Wang, L Liang, M Yu, W Wang, IH Badar, Y Bao… - Phytomedicine, 2024 - Elsevier
Background Cancer, the second leading cause of death worldwide following cardiovascular
diseases, presents a formidable challenge in clinical settings due to the extensive toxic side …

Paris polyphylla Sm. Induces Reactive Oxygen Species and Caspase 3-Mediated Apoptosis in Colorectal Cancer Cells In Vitro and Potentiates the Therapeutic …

V Kshetrimayum, R Heisnam, OS Keithellakpam… - Plants, 2023 - mdpi.com
Paris polyphylla Sm.(Melanthiaceae) is an essential, vulnerable herb with a wide range of
traditional applications ranging from fever to cancer in various communities. The use of P …

A review on Paris polyphylla Smith: A vulnerable medicinal plant species of a global significance

U Thakur, S Shashni, N Thakur, SK Rana… - Journal of Applied …, 2023 - Elsevier
Paris polyphylla Smith is an overexploited vulnerable medicinal plant species with its
distribution in the Himalayas and Southeast Asian Mountains. Due to its enormous …

Antioxidant, antibacterial, and cytotoxic effect of in vitro callus and in vivo rhizome of Paris polyphylla Sm

CB Thapa, HD Bhattarai, KK Pant, PR Joshi… - Process …, 2023 - Elsevier
This study aims to evaluate the antioxidant, antibacterial, and cytotoxicity activity of in vitro-
raised callus and in vivo-grown rhizome of the vulnerable medicinal plant Paris polyphylla …

Separation and Purification of Two Saponins from Paris polyphylla var. yunnanensis by a Macroporous Resin

X Zhang, J Wu, L Qin, G Wang, P Li, A Yu, A Liu, R Sun - Molecules, 2022 - mdpi.com
An effective method for separating and purifying critical saponins (polyphyllin II and
polyphyllin VII) from a Paris polyphylla var. yunnanensis extract was developed in this study …

Metabolomics and transcriptomics profiling of three Paris species with varied polyphyllin compositions

P Xu, J Chen, Q Mi, W Li, Y Lu, W Luo, M Yu, X Zhang… - Scientific Data, 2024 - nature.com
Most of the species in Paris have important medicinal values in China. Polyphyllins are the
key components in Paris, with varying levels and compositions among different species. This …