Engineering the multiscale complexity of vascular networks

C O'Connor, E Brady, Y Zheng, E Moore… - Nature Reviews …, 2022 - nature.com
The survival of vertebrate organisms depends on highly regulated delivery of oxygen and
nutrients through vascular networks that pervade nearly all tissues in the body …

[HTML][HTML] Vascular tissue engineering: progress, challenges, and clinical promise

HHG Song, RT Rumma, CK Ozaki, ER Edelman… - Cell stem cell, 2018 - cell.com
Although the clinical demand for bioengineered blood vessels continues to rise, current
options for vascular conduits remain limited. The synergistic combination of emerging …

High cell density and high-resolution 3D bioprinting for fabricating vascularized tissues

S You, Y Xiang, HH Hwang, DB Berry… - Science …, 2023 - science.org
Three-dimensional (3D) bioprinting techniques have emerged as the most popular methods
to fabricate 3D-engineered tissues; however, there are challenges in simultaneously …

3D bioprinting of engineered tissue flaps with hierarchical vessel networks (VesselNet) for direct host‐to‐implant perfusion

AA Szklanny, M Machour, I Redenski… - Advanced …, 2021 - Wiley Online Library
Engineering hierarchical vasculatures is critical for creating implantable functional thick
tissues. Current approaches focus on fabricating mesoscale vessels for implantation or …

3D printed complex tissue construct using stem cell-laden decellularized extracellular matrix bioinks for cardiac repair

J Jang, HJ Park, SW Kim, H Kim, JY Park, SJ Na… - Biomaterials, 2017 - Elsevier
Stem cell therapy is a promising therapeutic method for the treatment of ischemic heart
diseases; however, some challenges prohibit the efficacy after cell delivery due to hostile …

Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting

X Ma, X Qu, W Zhu, YS Li, S Yuan… - Proceedings of the …, 2016 - National Acad Sciences
The functional maturation and preservation of hepatic cells derived from human induced
pluripotent stem cells (hiPSCs) are essential to personalized in vitro drug screening and …

Direct 3D bioprinting of prevascularized tissue constructs with complex microarchitecture

W Zhu, X Qu, J Zhu, X Ma, S Patel, J Liu, P Wang… - Biomaterials, 2017 - Elsevier
Living tissues rely heavily on vascular networks to transport nutrients, oxygen and metabolic
waste. However, there still remains a need for a simple and efficient approach to engineer …

Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis

B Zhang, M Montgomery, MD Chamberlain, S Ogawa… - Nature materials, 2016 - nature.com
We report the fabrication of a scaffold (hereafter referred to as AngioChip) that supports the
assembly of parenchymal cells on a mechanically tunable matrix surrounding a perfusable …

Bioprinted osteogenic and vasculogenic patterns for engineering 3D bone tissue

B Byambaa, N Annabi, K Yue… - Advanced …, 2017 - Wiley Online Library
Fabricating 3D large‐scale bone tissue constructs with functional vasculature has been a
particular challenge in engineering tissues suitable for repairing large bone defects. To …

3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling

X Ma, J Liu, W Zhu, M Tang, N Lawrence, C Yu… - Advanced drug delivery …, 2018 - Elsevier
Abstract 3D bioprinting is emerging as a promising technology for fabricating complex tissue
constructs with tailored biological components and mechanical properties. Recent advances …