The liver is an essential organ that is critical for the removal of toxins, the production of
proteins, and the maintenance of metabolic homeostasis. Behind each liver functional unit …

Adult hepatocyte identity is constructed throughout embryonic development and fine-tuned
after birth. A multinodular network of transcription factors, along with pre-mRNA splicing …

Adult liver has enormous regenerative capacity; it can regenerate after losing two-thirds of its
mass while sustaining essential metabolic functions. How the liver balances dual demands …

Mechanisms underlying human hepatocyte growth in development and regeneration are
incompletely understood. In vitro, human fetal hepatocytes (FH) can be robustly grown as …

Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear
receptor family whose expression and activities are restricted to a limited number of organs …

Identifying new pathways that regulate mammalian regeneration is challenging due to the
paucity of in vivo screening approaches. We employed pooled CRISPR knockout and …

The adult liver has an exceptional ability to regenerate, but how it maintains its specialized
functions during regeneration is unclear. Here, we used partial hepatectomy (PHx) in …

Genetic sharing is extensively observed for autoimmune diseases, but the causal variants
and their underlying molecular mechanisms remain largely unknown. Through systematic …

The dynamic regulation of chromatin accessibility is one of the prominent characteristics of
eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which …

To gain deeper insights into transcriptomes and epigenomes of organoids, liver organoids
from two states (expandable and more differentiated) were subjected to single-cell RNA-seq …