The emerging threat of (micro) thrombosis in COVID-19 and its therapeutic implications

JD McFadyen, H Stevens, K Peter - Circulation research, 2020 - Am Heart Assoc
The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing global pandemic has presented a health emergency of unprecedented …

Lipoprotein (a) and cardiovascular disease

PR Kamstrup - Clinical chemistry, 2021 - academic.oup.com
Background High lipoprotein (a) concentrations present in 10%–20% of the population have
long been linked to increased risk of ischemic cardiovascular disease. It is unclear whether …

Lp (a)(lipoprotein [a]) concentrations and incident atherosclerotic cardiovascular disease: new insights from a large national biobank

AP Patel, M Wang, JP Pirruccello… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lp (a)(lipoprotein [a]) concentrations are associated with atherosclerotic
cardiovascular disease (ASCVD), and new therapies that enable potent and specific …

Single ascending dose study of a short interfering RNA targeting lipoprotein (a) production in individuals with elevated plasma lipoprotein (a) levels

SE Nissen, K Wolski, C Balog, DI Swerdlow… - Jama, 2022 - jamanetwork.com
Importance Lipoprotein (a)(Lp [a]) is an important risk factor for atherothrombotic
cardiovascular disease and aortic stenosis, for which there are no treatments approved by …

Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017

M Kinoshita, K Yokote, H Arai, M Iida… - … of atherosclerosis and …, 2018 - jstage.jst.go.jp
Every 5 years, the JAS publishes guidelines for the treatment of dyslipidemia and
atherosclerosis. To date, this society has released four such guidelines. Since 2007, the JAS …

Effect of pelacarsen on lipoprotein (a) cholesterol and corrected low-density lipoprotein cholesterol

C Yeang, E Karwatowska-Prokopczuk, F Su… - Journal of the American …, 2022 - jacc.org
Background Laboratory methods that report low-density lipoprotein cholesterol (LDL-C)
include both LDL-C and lipoprotein (a) cholesterol [Lp (a)-C] content. Objectives The …

Association of lipoprotein (a) with atherosclerotic plaque progression

Y Kaiser, M Daghem, E Tzolos, MN Meah… - Journal of the American …, 2022 - jacc.org
Abstract Background Lipoprotein (a)[Lp (a)] is associated with increased risk of myocardial
infarction, although the mechanism for this observation remains uncertain. Objectives This …

Oxidized phospholipids on lipoprotein (a) elicit arterial wall inflammation and an inflammatory monocyte response in humans

FM van der Valk, S Bekkering, J Kroon, C Yeang… - Circulation, 2016 - Am Heart Assoc
Background: Elevated lipoprotein (a)[Lp (a)] is a prevalent, independent cardiovascular risk
factor, but the underlying mechanisms responsible for its pathogenicity are poorly defined …

[HTML][HTML] The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on …

C Vlachopoulos, P Xaplanteris, V Aboyans… - Atherosclerosis, 2015 - Elsevier
While risk scores are invaluable tools for adapted preventive strategies, a significant gap
exists between predicted and actual event rates. Additional tools to further stratify the risk of …

Structure, function, and genetics of lipoprotein (a)

K Schmidt, A Noureen, F Kronenberg… - Journal of lipid …, 2016 - ASBMB
Lipoprotein (a)[Lp (a)] has attracted the interest of researchers and physicians due to its
intriguing properties, including an intragenic multiallelic copy number variation in the LPA …