Sickle-cell disease is one of the most common severe monogenic disorders in the world.
Haemoglobin polymerisation, leading to erythrocyte rigidity and vaso-occlusion, is central to …

This review presents evidence for two overlapping yet distinctive clinical types of sickle cell
disease. The basis of one is the vaso-occlusive crisis; the other is the consequence of …

Background Oxidative stress contributes to the complex pathophysiology of sickle cell
disease. Oral therapy with pharmaceutical-grade l-glutamine (USAN, glutamine) has been …

This document was approved by the American College of Cardiology Foundation (ACCF)
Board of Trustees in August 2012 and by the following societies in August 2012: American …

Background Little is known about the national outcome of children and adults with sickle cell
disease (SCD) given contemporary care. Procedure We investigated the number of deaths …

Purpose Pulmonary vascular dysfunction is common during acute respiratory distress
syndrome (ARDS), but there is controversy concerning prevalence and prognosis of cor …

This work was carried out to evaluate the levels of trace elements among sickle cell anaemia
patients attending Imo State Specialist Hospital, Owerri. Thirty subjects were recruited which …

Acute chest syndrome (ACS) is a frequent cause of acute lung disease in children with sickle
cell disease (SCD). Patients may present with ACS or may develop this complication during …

Sickle cell disease is characterized by recurrent episodes of ischemia-reperfusion injury to
multiple vital organ systems and a chronic hemolytic anemia, both contributing to …

Sickle cell disease has been very well characterized as a single amino acid molecular
disorder of hemoglobin leading to its pathological polymerization, with resulting red cell …