There is extensive evidence that effective screening for major chromosomal abnormalities
can be provided in the first trimester of pregnancy. Prospective studies in a total of 200,868 …

Summarizes the areas related to the fetal cells in the maternal blood for prenatal diagnosis.
Difference between trophoblast sprouts and nucleated erythrocytes; Mechanisms that …

Background Screening for aneuploid pregnancies is routinely performed after 15 weeks of
gestation and has a sensitivity of approximately 65 percent, with a false positive rate of 5 …

Objective To examine the potential impact of combining maternal age with fetal nuchal
translucency thickness and maternal serum free β‐human chorionic gonadotropin (β‐hCG) …

Background Both first-trimester screening and second-trimester screening for Down's
syndrome are effective means of selecting women for chorionic-villus sampling or …

Abstract Objective To develop a Canadian consensus document on maternal screening for
fetal aneuploidy (eg, Down syndrome and trisomy 18) in singleton pregnancies. Options …

We have recently demonstrated the existence of a neuromodulatory regulation of prolactin
secretion by the opioid system showing a paradoxical opioid-induced prolactin suppression …

Meta‐analysis was used to calculate maternal serum marker distribution parameters for
Down syndrome risk estimation in the first trimester. Data from 44 series were combined …

ContextPrenatal diagnosis and termination of affected pregnancies can prevent infant
deaths due to congenital anomalies, but an effect at the population level has not been …

Brambati et al reported that first trimester maternal serum concentrations of pregnancy
associated plasma protein A (PAPP-A) were low in pregnancies associated with fetal …