Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

Totipotent cells have more robust developmental potency than any other cell types, giving
rise to both embryonic and extraembryonic tissues. Stable totipotent cell cultures and …

The dynamic and reversible acetylation of proteins, catalysed by histone acetyltransferases
(HATs) and histone deacetylases (HDACs), is a major epigenetic regulatory mechanism of …

Protein lysine methylation is a distinct posttranslational modification that causes minimal
changes in the size and electrostatic status of lysine residues. Lysine methylation plays …

DNA methylation and trimethylated histone H4 Lysine 20 (H4K20me3) constitute two
important heterochromatin-enriched marks that frequently cooperate in silencing repetitive …

Cellular senescence is a well-orchestrated programmed process involved in age-related
pathologies, tumor suppression and embryonic development. TGF-β/Smad is one of the …

Cellular DNA is constantly being damaged by numerous internal and external mutagenic
factors. Probably the most severe type of insults DNA could suffer are the double-strand …

Protein methyltransferases (PMTs) comprise a major class of epigenetic regulatory enzymes
with therapeutic relevance. Here we present a collection of chemical probes and associated …

The bivalent histone modification reader 53BP1 accumulates around DNA double-strand
breaks (DSBs), where it dictates repair pathway choice decisions by limiting DNA end …