The effects of chronic stress on the human brain: From neurotoxicity, to vulnerability, to opportunity

SJ Lupien, RP Juster, C Raymond, MF Marin - Frontiers in …, 2018 - Elsevier
For the last five decades, science has managed to delineate the mechanisms by which
stress hormones can impact on the human brain. Receptors for glucocorticoids are found in …

In pursuit of resilience: stress, epigenetics, and brain plasticity

BS McEwen - Annals of the New York Academy of Sciences, 2016 - Wiley Online Library
The brain is the central organ for adaptation to experiences, including stressors, which are
capable of changing brain architecture as well as altering systemic function through …

[HTML][HTML] Recognizing resilience: Learning from the effects of stress on the brain

BS McEwen, JD Gray, C Nasca - Neurobiology of stress, 2015 - Elsevier
As the central organ of stress and adaptation to stressors, the brain plays a pivotal role in
behavioral and physiological responses that may lead to successful adaptation or to …

Insufficient antibody validation challenges oestrogen receptor beta research

S Andersson, M Sundberg, N Pristovsek… - Nature …, 2017 - nature.com
The discovery of oestrogen receptor β (ERβ/ESR2) was a landmark discovery. Its reported
expression and homology with breast cancer pharmacological target ERα (ESR1) raised …

Role of estrogen receptor alpha and beta expression and signaling on cognitive function during aging

TC Foster - Hippocampus, 2012 - Wiley Online Library
This review presents evidence for the idea that the expression of estrogen receptor alpha
and beta (ERα and ERβ) interacts with the level of estradiol (E2) to influence the etiology of …

Estrogen receptor-β signaling modulates epithelial barrier function

M Looijer-van Langen, N Hotte… - American Journal …, 2011 - journals.physiology.org
Impaired epithelial barrier function and estrogens are recognized as factors influencing
inflammatory bowel disease (IBD) pathology and disease course. Estrogen receptor-β (ERβ) …

Insights into rapid modulation of neuroplasticity by brain estrogens

DP Srivastava, KM Woolfrey, P Penzes… - Pharmacological …, 2013 - Elsevier
Converging evidence from cellular, electrophysiological, anatomic, and behavioral studies
suggests that the remodeling of synapse structure and function is a critical component of …

GPER1/GPR30 in the brain: crosstalk with classical estrogen receptors and implications for behavior

MM Hadjimarkou, N Vasudevan - The Journal of Steroid Biochemistry and …, 2018 - Elsevier
The GPER1/GPR30 is a membrane estrogen receptor (mER) that binds 17β-estradiol (17β-
E) with high affinity and is thought to play a role in cancer progression and cardiovascular …

Estrus-cycle regulation of cortical inhibition

AM Clemens, C Lenschow, P Beed, L Li, R Sammons… - Current Biology, 2019 - cell.com
Female mammals experience cyclical changes in sexual receptivity known as the estrus
cycle. Little is known about how estrus affects the cortex, although alterations in sensation …

Estrogen receptor β expression in the mouse forebrain: age and sex differences

DG Zuloaga, KL Zuloaga, LR Hinds… - Journal of …, 2014 - Wiley Online Library
Estrogen receptors regulate multiple brain functions, including stress, sexual, and memory‐
associated behaviors as well as controlling neuroendocrine and autonomic function. During …