With biotechnological advancements, innovative omics technologies are constantly
emerging that have enabled researchers to access multi-layer information from the genome …

Molecular imaging has experienced enormous advancements in the areas of imaging
technology, imaging probe and contrast development, and data quality, as well as machine …

The data-driven identification of disease states and treatment options is a crucial challenge
for precision oncology. Artificial intelligence (AI) offers unique opportunities for enhancing …

Background As technical developments in omics and biomedical imaging increase the
throughput of data generation in life sciences, the need for information systems capable of …

In oncology, intratumoural heterogeneity is closely linked with the efficacy of therapy, and
can be partially characterized via tumour biopsies. Here we show that intratumoural …

It is well-recognized that solid tumors are genomically, anatomically, and physiologically
heterogeneous. In general, more heterogeneous tumors have poorer outcomes, likely due to …

Metabolic reprogramming drives the development of an immunosuppressive tumor
microenvironment (TME) through various pathways, contributing to cancer progression and …

The proper communication between gut and brain is pivotal for the maintenance of health
and, dysregulation of the gut-brain axis can lead to several clinical disorders. In Parkinson's …

Purpose Tumor hypoxia and other microenvironmental factors are key determinants of
treatment resistance. Hypoxia positron emission tomography (PET) and functional magnetic …

PURPOSE Spatial heterogeneity of tumors is a major challenge in precision oncology. The
relationship between molecular and imaging heterogeneity is still poorly understood …