Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

In the past few decades, the field of neuroepigenetics has investigated how the brain
encodes information to form long-lasting memories that lead to stable changes in behaviour …

Neurons derived from human induced Pluripotent Stem Cells (hiPSCs) provide a promising
new tool for studying neurological disorders. In the past decade, many protocols for …

Kleefstra syndrome (KS) is a neurodevelopmental disorder caused by mutations in the
histone methyltransferase EHMT1. To study the impact of decreased EHMT1 function in …

Kleefstra syndrome, caused by haploinsufficiency of euchromatin histone methyltransferase
1 (EHMT1), is characterized by intellectual disability (ID), autism spectrum disorder (ASD) …

Epigenetic dysregulation, which leads to the alteration of gene expression in the brain, is
suggested as one of the key pathophysiological bases of ageing and neurodegeneration …

Intellectual disability (ID) is a prevailing neurodevelopmental condition associated with
impaired cognitive and adaptive behaviors. Many chromatin-modifying enzymes and other …

Mutations in one SETD5 allele are genetic causes of intellectual disability and autistic
spectrum disorders. However, the mechanisms by which SETD5 regulates brain …

Macroautophagy/autophagy is an evolutionarily highly conserved catabolic process that is
important for the clearance of cytosolic contents to maintain cellular homeostasis and …

Destabilization of neural activity caused by failures of homeostatic regulation has been
hypothesized to drive the progression of Alzheimer's Disease (AD). However, the …