[HTML][HTML] Recent advances in the understanding and management of liposarcoma

CL Haddox, RF Riedel - Faculty reviews, 2021 - ncbi.nlm.nih.gov
Liposarcomas are a common subfamily of soft tissue sarcoma with several subtypes
recognized by the World Health Organization: atypical lipomatous tumors (ALT)/well …

[HTML][HTML] Targeted and immuno-based therapies in sarcoma: mechanisms and advances in clinical trials

F Tang, Y Tie, YQ Wei, CQ Tu, XW Wei - Biochimica et Biophysica Acta …, 2021 - Elsevier
Sarcomas represent a distinct group of rare malignant tumors with high heterogeneity.
Limited options with clinical efficacy for the metastatic or local advanced sarcoma existed …

Integrated screens identify CDK1 as a therapeutic target in advanced gastrointestinal stromal tumors

X Lu, Y Pang, H Cao, X Liu, L Tu, Y Shen, X Jia, JC Lee… - Cancer Research, 2021 - AACR
Oncogenic KIT or PDGFRA receptor tyrosine kinase mutations are compelling therapeutic
targets in gastrointestinal stromal tumor (GIST), and treatment with the KIT/PDGFRA inhibitor …

Established and experimental systemic treatment options for advanced liposarcoma

P Schöffski - Oncology research and treatment, 2022 - karger.com
Background: While soft-tissue sarcomas (STSs) are rare tumors, liposarcomas are among
the most common type of STS and are divided into four main subtypes: atypical lipomatous …

MicroRNA-191 regulates oral squamous cell carcinoma cells growth by targeting PLCD1 via the Wnt/β-catenin signaling pathway

Z Wang, W Guan, Y Ma, X Zhou, G Song, J Wei… - BMC cancer, 2023 - Springer
Background Studies have shown that microRNA-191 (miR-191) is involved in the
development and progression of a variety of tumors. However, the function and mechanism …

Immunotherapy for sarcomas

E Nakata, T Fujiwara, T Kunisada, T Ito… - Japanese journal of …, 2021 - academic.oup.com
Sarcomas are a heterogeneous group of malignancies of mesenchymal origin; their
molecular and genomic mechanisms differ with regard to histology. These characteristics …

Biology-guided precision medicine in rare cancers: Lessons from sarcomas and neuroendocrine tumours

WTA Van Der Graaf, MET Tesselaar… - Seminars in Cancer …, 2022 - Elsevier
Rare cancers, which collectively account for almost 25% of all malignancies, are poorly
understood in terms of their aetiology and pathogenesis and are infrequently the focus of …

The role of CDK pathway dysregulation and its therapeutic potential in soft tissue sarcoma

JT Thiel, A Daigeler, J Kolbenschlag, K Rachunek… - Cancers, 2022 - mdpi.com
Simple Summary Soft tissue sarcomas (STSs) are rare malignant conditions with more than
70 subtypes that are difficult to treat, especially in advanced or metastatic states. Recently …

Overview of systemic therapy options in liposarcoma, with a focus on the activity of selinexor, a selective inhibitor of nuclear export in dedifferentiated liposarcoma

P Thirasastr, N Somaiah - Therapeutic Advances in Medical …, 2022 - journals.sagepub.com
Liposarcoma (LPS) is a common soft tissue sarcoma that encompasses diverse subtypes of
well-differentiated/dedifferentiated, myxoid/round cell, and pleomorphic LPS. There is …

The cyclin-dependent kinases pathway as a target for prostate cancer treatment: rationale and future perspectives

N Brighi, V Conteduca, C Lolli, G Gurioli… - Critical reviews in …, 2021 - Elsevier
The rapidly expanding scenario of treatment options for patients affected by prostate cancer
(PC) is leading to improved outcomes; however, PC still represents one of the most frequent …