Proteolytic removal of membrane protein ectodomains (ectodomain shedding) is a post‐
translational modification that controls levels and function of hundreds of membrane …

Accumulations of insoluble deposits of amyloid β-peptide are major pathological hallmarks
of Alzheimer disease. Amyloid β-peptide is derived by sequential proteolytic processing from …

Ferroptosis is an iron-and lipid peroxidation (LPO)-mediated programmed cell death type.
Recently, mounting evidence has indicated the involvement of ferroptosis in …

An important pathological feature of Alzheimer's disease (AD) is the presence of
extracellular senile plaques in the brain. Senile plaques are composed of aggregations of …

The Alzheimer's disease (AD)-associated amyloid-β protein precursor (AβPP) is cleaved by
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …

BACE1 (β-secretase, memapsin 2, Asp2) has emerged as a promising target for the
treatment of Alzheimer's disease. BACE1 is an aspartic protease which functions in the first …

Formation of senile plaques containing the β-amyloid peptide (Aβ) derived from the amyloid
precursor protein (APP) is an invariant feature of Alzheimer's disease (AD). APP is cleaved …

The β-amyloid (Aβ) peptide is the major constituent of amyloid plaques in Alzheimer's
disease (AD) brain and is likely to play a central role in the pathogenesis of this devastating …

Amyloid-β precursor protein (APP) is a membrane-spanning protein with a large
extracellular domain and a much smaller intracellular domain. It is the source of the amyloid …

Autophagy is the sole pathway for organelle turnover in cells and is a vital pathway for
degrading normal and aggregated proteins, particularly under stress or injury conditions …