Abstract BCR:: ABL1-negative myeloproliferative neoplasms (MPNs) are clonal diseases
originating from a single hematopoietic stem cell that cause excessive production of mature …

Clonal alterations in hematopoietic cells occur during aging and are often associated with
the establishment of a subclinical inflammatory environment. Several age-related conditions …

The goal of therapy for patients with essential thrombocythemia (ET) and polycythemia vera
(PV) is to reduce thrombotic events by normalizing blood counts. Hydroxyurea (HU) and …

Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the
excessive production of mature myeloid cells and arise from the acquisition of somatic driver …

Substantial progress has been made in our understanding of the pathogenetic basis of
myeloproliferative neoplasms. The discovery of mutations in JAK2 over a decade ago …

Thrombotic, vascular, and bleeding complications are the most common causes of morbidity
and mortality in the Philadelphia chromosome–negative myeloproliferative neoplasms …

Janus kinase 2 (valine to phenylalanine at residue 617)(JAK2 V617F) mutations lead to
myeloproliferative neoplasms associated with elevated myeloid, erythroid, and …

Myeloproliferative neoplasms (MPNs) arise in the hematopoietic stem cell (HSC)
compartment as a result of the acquisition of somatic mutations in a single HSC that provides …

Increasing evidence shows that conventional cardiovascular risk factors are incompletely
predictive of cardiovascular disease, particularly in elderly individuals, suggesting that there …

JAK2-V617F–positive chronic myeloproliferative neoplasia (CMN) commonly displays
dysfunction of integrins and adhesion molecules expressed on platelets, erythrocytes, and …