Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae

T Jordá, S Puig - Genes, 2020 - mdpi.com
Ergosterol is an essential component of fungal cell membranes that determines the fluidity,
permeability and activity of membrane-associated proteins. Ergosterol biosynthesis is a …

[HTML][HTML] Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention

LM Butler, Y Perone, J Dehairs, LE Lupien… - Advanced drug delivery …, 2020 - Elsevier
With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

SREBP-regulated lipid metabolism: convergent physiology—divergent pathophysiology

H Shimano, R Sato - Nature Reviews Endocrinology, 2017 - nature.com
Cellular lipid metabolism and homeostasis are controlled by sterol regulatory-element
binding proteins (SREBPs). In addition to performing canonical functions in the …

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

H Miess, B Dankworth, AM Gouw, M Rosenfeldt… - Oncogene, 2018 - nature.com
Metabolic reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC).
Here we investigated metabolic dependencies in a panel of ccRCC cell lines using nutrient …

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

F Baenke, B Peck, H Miess… - Disease models & …, 2013 - journals.biologists.com
An increased rate of lipid synthesis in cancerous tissues has long been recognised as an
important aspect of the rewired metabolism of transformed cells. However, the contribution of …

Targeting SREBP-1-mediated lipogenesis as potential strategies for cancer

Q Zhao, X Lin, G Wang - Frontiers in oncology, 2022 - frontiersin.org
Sterol regulatory element binding protein-1 (SREBP-1), a transcription factor with a basic
helix–loop–helix leucine zipper, has two isoforms, SREBP-1a and SREBP-1c, derived from …

Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis

TRT Dagenais, NP Keller - Clinical microbiology reviews, 2009 - Am Soc Microbiol
Aspergillus species are globally ubiquitous saprophytes found in a variety of ecological
niches. Almost 200 species of aspergilli have been identified, less than 20 of which are …

SREBPs: metabolic integrators in physiology and metabolism

TI Jeon, TF Osborne - Trends in Endocrinology & Metabolism, 2012 - cell.com
Recent advances have significantly increased our understanding of how sterol regulatory
element binding proteins (SREBPs) are regulated at the transcriptional and post …

Early steps in steroidogenesis: intracellular cholesterol trafficking: thematic review series: genetics of human lipid diseases

WL Miller, HS Bose - Journal of lipid research, 2011 - ASBMB
Steroid hormones are made from cholesterol, primarily derived from lipoproteins that enter
cells via receptor-mediated endocytosis. In endo-lysosomes, cholesterol is released from …

Regulation of sterol synthesis in eukaryotes

PJ Espenshade, AL Hughes - Annu. Rev. Genet., 2007 - annualreviews.org
Cholesterol is an essential component of mammalian cell membranes and is required for
proper membrane permeability, fluidity, organelle identity, and protein function. Cells …