Senescent cells, which accumulate in organisms over time, contribute to age-related tissue
decline. Genetic ablation of senescent cells can ameliorate various age-related pathologies …

Emerging new evidence highlights the importance of prolonged daily fasting periods for the
health and survival benefits of calorie restriction (CR) and time-restricted feeding (TRF) in …

Canagliflozin (Cana) is an FDA-approved diabetes drug that protects against cardiovascular
and kidney diseases. It also inhibits the sodium glucose transporter 2 by blocking renal …

Canagliflozin (Cana), a clinically important anti-diabetes drug, leads to a 14% increase in
median lifespan and a 9% increase in the 90th percentile age when given to genetically …

Pharmaceutical intervention of aging requires targeting multiple pathways, thus there is
rationale to test combinations of drugs targeting different but overlapping processes. In order …

Chlamydia muridarum (Cm) was detected in 2 colonies of mice with lymphoplasmacytic
pulmonary infiltrates by using PCR and immunohistochemistry. This discovery was …

Inclusion body nephropathy (IBN) and kidney fibrosis in aged immunodeficient mice and, to
lesser extent, in immunocompetent mice have been recently linked to infection of mouse …

The ability to quantify aging-related changes in histological samples is important, as it allows
for evaluation of interventions intended to effect health span. We used a machine learning …

The overarching mission of the Einstein-Nathan Shock Center (E-NSC) is to make scientific
discoveries in geroscience, leveraging on the expertise in our center in 6 out of the 7 pillars …

Aging is a complex multidimensional process of progressive decline affecting multiple organ
systems by a number of processes that are still not well understood. While many studies …