Cutaneous lesions in patients with mastocytosis are highly heterogeneous and encompass
localized and disseminated forms. Although a classification and criteria for cutaneous …

Although a classification for mastocytosis and diagnostic criteria are available, there remains
a need to define standards for the application of diagnostic tests, clinical evaluations, and …

Advanced systemic mastocytosis (AdvSM) is a rare hematologic neoplasm driven by the KIT
D816V mutation and associated with poor survival. This phase 1 study (NCT02561988) …

Paediatric mastocytosis was previously considered to be a benign and spontaneously
regressing disease. However, this evolution is impossible to predict. To clarify the …

Adult mastocytosis is an incurable clonal disease associated with c-KIT mutations, mostly in
exon 17 (D 816 V). In contrast, pediatric mastocytosis often spontaneously regresses and is …

Signaling by stem cell factor and Kit, its receptor, play important roles in gametogenesis,
hematopoiesis, mast cell development and function, and melanogenesis. Moreover, human …

Background The WHO classification separates mastocytosis into distinct variants, but
prognostication remains a clinical challenge. The aim of this study was to improve …

Mast cell leukemia (MCL) is a very rare form of aggressive systemic mastocytosis accounting
for< 1% of all mastocytosis. It may appear de novo or secondary to previous mastocytosis …

Mastocytosis is an emerging differential diagnosis in patients with more or less specific
mediator‐related symptoms. In some of these patients, typical skin lesions are found and the …

IgE, mast cells, basophils, and eosinophils constitute essential elements in allergic
inflammation. Allergen-specific IgE, synthesized in response to allergens in the environment …