Chiral amines are pivotal building blocks for the pharmaceutical industry. Asymmetric
reductive amination is one of the most efficient and atom economic methodologies for the …

Reductions play a key role in organic synthesis, producing chiral products with new
functionalities. Enzymes can catalyse such reactions with exquisite stereo‐, regio‐and …

As the enzyme toolbox for biocatalysis has expanded, so has the potential for the
construction of powerful enzymatic cascades for efficient and selective synthesis of target …

Chiral amine diastereomers are ubiquitous in pharmaceuticals and agrochemicals, yet their
preparation often relies on low-efficiency multi-step synthesis. These valuable compounds …

The synthesis of secondary and tertiary amines through the reductive amination of carbonyl
compounds is one of the most significant reactions in synthetic chemistry. Asymmetric …

Biocatalysis integrate microbiologists, enzymologists, and organic chemists to access the
repertoire of pharmaceutical and agrochemicals with high chemoselectivity, regioselectivity …

Photoenzymes are biological catalysts that use light to convert starting materials into
products. These catalysts require photon absorption for each turnover, making quantum …

Enzymes, at the turn of the 21st century, are gaining a momentum. Especially in the field of
synthetic organic chemistry, a broad variety of biocatalysts are being applied in an …

Enzyme cascades are efficient tools to perform multi-step synthesis in one-pot in a green
and sustainable manner, enabling non-natural synthesis of valuable chemicals from easily …

The efficient asymmetric catalytic synthesis of amines containing more than one stereogenic
center is a current challenge. Here, we present a biocatalytic cascade that combines ene …