Rheumatoid arthritis (RA) is a classic autoimmune disease characterized by uncontrolled
synovial proliferation, pannus formation, cartilage injury, and bone destruction. The specific …

TIGAR (TP53-induced glycolysis and apoptosis regulator) is the downstream target gene of
p53, contains a functional sequence similar to 6-phosphofructose kinase/fructose-2, 6 …

Nicotinamide adenine dinucleotide (NAD) replenishment therapy using nicotinamide
riboside (NR) shows promise for Parkinson's disease (PD) and other neurodegenerative …

Background Therapies are urgently required to ameliorate pathological cardiac hypertrophy
and enhance cardiac function in heart failure. Our preliminary experiments have …

Background Parkinson's disease (PD) is the second most frequent age-related
neurodegenerative disorder and is characterized by the loss of dopaminergic neurons. Both …

Abnormal accumulation of α-synuclein and mitochondria dynamics dysfunction are
considered to be implicated in the pathogenesis of Parkinson's disease. However, the …

The current study investigated the physiological mechanisms by which extracellular vesicle
(EV)-encapsulated miR-181a–2–3p derived from mesenchymal stem cells (MSCs) might …

The present review reports a list of approximately 800 compounds which have been used,
tested or proposed for Parkinson's disease (PD) therapy in the year range 2014–2019 …

Significance: The significant role of reduced nicotinamide adenine dinucleotide phosphate
(NADPH) oxidase (Nox) in signal transduction is mediated by the production of reactive …

Cerebral ischemia is a disease of ischemic necrosis of brain tissue caused by intracranial
artery stenosis or occlusion and cerebral artery embolization. Neuroinflammation plays an …