Carbonic anhydrases (CAs, EC 4.2. 1.1) are ubiquitous metallo-enzymes, present
throughout most living organisms and encoded by five evolutionarily unrelated gene …

Estrogen governs the regulations of various pathological and physiological actions
throughout the body in both males and females. Generally, 17β-estradiol an endogenous …

Cancer is a complex disease since it is adaptive in such a way that it can promote
proliferation and invasion by means of an overactive cell cycle and in turn cellular division …

Cytochrome P450 enzymes that metabolize estrogens are expressed in the mammary
gland, uterus, brain and other target tissues for estrogen action, and this results in the …

Covering: up to 2012 Steroids, a widespread class of natural organic compounds occurring
in animals, plants and fungi, have shown great therapeutic value for a broad array of …

Estrogens display intriguing tissue selective action that is of great biomedical importance in
the development of optimal therapeutics for the prevention and treatment of breast cancer …

Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates and
therefore has a pivotal role in regulating the formation of biologically active steroids. The …

Sulfatases, which cleave sulfate esters in biological systems, play a key role in regulating
the sulfation states that determine the function of many physiological molecules. Sulfatase …

2, 3-Disubstituted benzo [b] furans are prepared in one step from commercially available
phenols and readily accessible unactivated internal alkynes (see scheme). This Pd …

Starting from the very simple molecule sulfamic acid, O‐substituted‐, N‐substituted‐, or di‐
/tri‐substituted sulfamates may be obtained, which show specific biological activities which …