Background: Beta-site Amyloid precursor protein Cleaving Enzyme 1 (BACE1) is conceived
as a potential target for therapies against Alzheimer disease (AD) which is characterized by …

Aminobenzotriazole (1-ABT) is a pan-specific, mechanism-based inactivator of the
xenobiotic metabolizing forms of cytochrome P450 in animals, plants, insects, and …

The solvent-free reaction of 4-alkylidene pyrazolones with amidines can furnish 4, 5′-
imidazolinyl spiropyrazolones in good to excellent yields when promoted by N …

A novel N-iodosuccinimide-promoted intermolecular cyclization between alkenes and
amidines has been demonstrated under solvent-free ball-milling conditions, affording a …

Scientists working in the field of Alzheimer's disease and, in particular, cognitive enhancers
are very productive. The review on Drugs interacting with Enzymes was accepted in August …

Background: Alzheimer's disease (AD) is the most common neurodegenerative disease, and
the accumulation of amyloid-β is the initial process in AD. MicroRNAs (miRNAs) are widely …

A CuBr2-catalyzed cascade reaction of amidines with exocyclic α, β-unsaturated
cycloketones was developed, affording a large variety of spiroimidazolines in moderate to …

A selective cyclization of unsaturated barbiturates and amidines promoted by N-
bromosuccinimide has been successfully developed to afford a vast variety of 5, 4 …

A novel Cu-catalyzed synthesis of structurally valuable spiroimidazole derivatives from 2-
(indol-3-yl) cyclohexanones and amidines via an indolyl mediated cyclization …

In the past 20 years, several novel data-mining methods, inclining mass defect filtering,
background subtraction, isotope pattern filtering, and metabolomics analysis, have been …