In vivo direct imaging of neuronal activity at high temporospatial resolution

PT Toi, HJ Jang, K Min, SP Kim, SK Lee, J Lee, J Kwag… - Science, 2022 - science.org
There has been a long-standing demand for noninvasive neuroimaging methods that can
detect neuronal activity at both high temporal and high spatial resolution. We present a two …

Revealing architectural order with quantitative label-free imaging and deep learning

SM Guo, LH Yeh, J Folkesson, IE Ivanov, AP Krishnan… - elife, 2020 - elifesciences.org
We report quantitative label-free imaging with phase and polarization (QLIPP) for
simultaneous measurement of density, anisotropy, and orientation of structures in unlabeled …

[HTML][HTML] A rapid-onset diffusion functional MRI signal reflects neuromorphological coupling dynamics

D Nunes, R Gil, N Shemesh - NeuroImage, 2021 - Elsevier
Abstract Functional Magnetic Resonance Imaging (fMRI) has transformed our understanding
of brain function in-vivo. However, the neurovascular coupling mechanisms underlying fMRI …

Quantitative birefringence microscopy for imaging the structural integrity of CNS myelin following circumscribed cortical injury in the rhesus monkey

N Blanke, V Go, DL Rosene, IJ Bigio - Neurophotonics, 2021 - spiedigitallibrary.org
Significance: Myelin breakdown is likely a key factor in the loss of cognitive and motor
function associated with many neurodegenerative diseases. Aim: New methods for imaging …

uPTI: uniaxial permittivity tensor imaging of intrinsic density and anisotropy

LH Yeh, IE Ivanov, SM Guo, BB Chhun… - Novel Techniques in …, 2021 - opg.optica.org
We present a label-free computational microscopy method, uPTI, which reports components
of uniaxial permittivity tensor, including phase and 3D anisotropy across volumes. We report …

Ultra-parallel label-free optophysiology of neural activity

RR Iyer, YZ Liu, CA Renteria, BE Tibble, H Choi… - Iscience, 2022 - cell.com
The electrical activity of neurons has a spatiotemporal footprint that spans three orders of
magnitude. Traditional electrophysiology lacks the spatial throughput to image the activity of …

Exploring the structure, metabolism, and biochemistry of the neuronal microenvironment label-free using fast simultaneous multimodal optical microscopy

RR Iyer, JE Sorrells, L Yang, CA Renteria, EJ Chaney… - Optica, 2024 - opg.optica.org
The technologies to examine the neuronal microenvironment label free remain critically
underexplored. There is a gap in our knowledge of underlying metabolic, biochemical, and …

Synthesis, Mesomorphism and the Optical Properties of Alkyl-deuterated Nematogenic 4-[(2, 6-Difluorophenyl) ethynyl] biphenyls

J Herman, P Harmata, M Czerwiński, O Strzeżysz… - Materials, 2021 - mdpi.com
The synthesis and characterization of new deuterated liquid crystal (LC) compounds based
on phenyl tolane core is described in this paper. The work presents an alternative molecular …

Revealing architectural order with quantitative label-free imaging and deep neural networks

SM Guo, LH Yeh, J Folkesson, IE Ivanov, AP Krishnan… - BioRxiv, 2019 - biorxiv.org
Methods for imaging architecture of biological systems are currently not as scalable as
genomic, transcriptomic, or proteomic technologies, because they rely on labels instead of …

Cutting-edge brain research from a biophysical perspective: symposium synopsis of Session 1SCP at BSJ2019 in Miyazaki, Kyushu, Japan

T Tominaga, B Kuhn - Biophysical Reviews, 2020 - Springer
The organizers Takashi Tominaga (Tokushima Bunri University) and Bernd Kuhn (OIST
Graduate University) planned the symposium with the idea that a biophysical perspective is …