Cellular and molecular aging biomarkers might contribute to identify at-risk individuals for
frailty before overt clinical manifestations appear. Although studies on the associations of …

Small heat shock proteins (sHSPs) are ATP-independent chaperones that delay formation of
harmful protein aggregates. sHSPs' role in protein homeostasis has been appreciated for …

Skeletal muscle and the nervous system depend on efficient protein quality control, and they
express chaperones and cochaperones at high levels to maintain protein homeostasis …

Heat shock proteins are important for maintaining protein homeostasis and cell survival.
Among different classes of highly conserved Hsps, low molecular weight Hsps (sHsps) have …

Defining the mechanisms safeguarding cell fate identity in differentiated cells is crucial to
improve 1)-our understanding of how differentiation is maintained in healthy tissues or …

The ability of cells to respond to stress is central to health. Stress can damage folded
proteins, which are vulnerable to even minor changes in cellular conditions. To maintain …

Steaks of 74 animals from 3 young bull breeds (Aberdeen Angus, Limousin and Blond
d'Aquitaine) were cooked at two end-point cooking temperatures (55 and 74° C) and …

From the viewpoint of the general pathology, most of the human diseases are associated
with a limited number of pathogenic processes such as inflammation, tumor growth …

Duchenne muscular dystrophy is the most common and severe of the muscular dystrophies,
a group of inherited myopathies caused by different genetic mutations leading to aberrant …

Protein aggregation increases with age in normal tissues, and with pathology and age in
Alzheimer's hippocampus and mouse cardiac muscle. We now ask whether human skeletal …