The implications of IDH mutations for cancer development and therapy
CJ Pirozzi, H Yan - Nature reviews Clinical oncology, 2021 - nature.com
Mutations in the genes encoding the cytoplasmic and mitochondrial forms of isocitrate
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …
The emerging hallmarks of cancer metabolism
NN Pavlova, CB Thompson - Cell metabolism, 2016 - cell.com
Tumorigenesis is dependent on the reprogramming of cellular metabolism as both direct
and indirect consequence of oncogenic mutations. A common feature of cancer cell …
and indirect consequence of oncogenic mutations. A common feature of cancer cell …
[HTML][HTML] IDH mutations in cancer and progress toward development of targeted therapeutics
L Dang, K Yen, EC Attar - Annals of Oncology, 2016 - Elsevier
ABSTRACT Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes,
converting isocitrate to α-ketoglutarate (αKG). IDH1 and IDH2 mutations have been …
converting isocitrate to α-ketoglutarate (αKG). IDH1 and IDH2 mutations have been …
The epigenomics of sarcoma
BA Nacev, KB Jones, AM Intlekofer, JSE Yu… - Nature Reviews …, 2020 - nature.com
Epigenetic regulation is critical to physiological control of development, cell fate, cell
proliferation, genomic integrity and, fundamentally, transcriptional regulation. This …
proliferation, genomic integrity and, fundamentally, transcriptional regulation. This …
Mutant IDH1 downregulates ATM and alters DNA repair and sensitivity to DNA damage independent of TET2
Mutations in the isocitrate dehydrogenase-1 gene (IDH1) are common drivers of acute
myeloid leukemia (AML) but their mechanism is not fully understood. It is thought that IDH1 …
myeloid leukemia (AML) but their mechanism is not fully understood. It is thought that IDH1 …
Molecular pathways: isocitrate dehydrogenase mutations in cancer
O Clark, K Yen, IK Mellinghoff - Clinical Cancer Research, 2016 - AACR
IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to α-
ketoglutarate (α-KG) and concomitantly produce reduced NADPH from NADP+. Mutations in …
ketoglutarate (α-KG) and concomitantly produce reduced NADPH from NADP+. Mutations in …
Phase I study of the mutant IDH1 inhibitor ivosidenib: safety and clinical activity in patients with advanced chondrosarcoma
WD Tap, VM Villalobos, GM Cote, H Burris… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Surgery is the primary therapy for localized chondrosarcoma; for locally
advanced and/or metastatic disease, no known effective systemic therapy exists. Mutations …
advanced and/or metastatic disease, no known effective systemic therapy exists. Mutations …
Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin
Q Deng, P Li, M Che, J Liu, S Biswas, G Ma, L He… - Elife, 2019 - elifesciences.org
Indian Hedgehog (IHH) signaling, a key regulator of skeletal development, is highly
activated in cartilage and bone tumors. Yet deletion of Ptch1, encoding an inhibitor of IHH …
activated in cartilage and bone tumors. Yet deletion of Ptch1, encoding an inhibitor of IHH …
Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates features of early gliomagenesis
C Bardella, O Al-Dalahmah, D Krell, P Brazauskas… - Cancer cell, 2016 - cell.com
Isocitrate dehydrogenase 1 mutations drive human gliomagenesis, probably through
neomorphic enzyme activity that produces D-2-hydroxyglutarate. To model this disease, we …
neomorphic enzyme activity that produces D-2-hydroxyglutarate. To model this disease, we …
Role of metabolism in bone development and homeostasis
Carbohydrates, fats, and proteins are the underlying energy sources for animals and are
catabolized through specific biochemical cascades involving numerous enzymes. The …
catabolized through specific biochemical cascades involving numerous enzymes. The …